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Rabbit Polyclonal EPS8L2 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human EPS8L2 aa 400-700.


Images

Western blot - Anti-EPS8L2 antibody (AB126155), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human EPS8L2 aa 400-700. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H6S3

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Target data

Function

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal EPS8L2 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human EPS8L2 aa 400-700.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human EPS8L2 aa 400-700. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H6S3
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

EPS8L2 also known as Epidermal Growth Factor Receptor Substrate 8-Like Protein 2 plays a mechanical role in cellular signaling and cytoskeletal organization. This protein has a molecular mass of approximately 97 kDa. EPS8L2 expresses in various tissues including the brain liver and testis where it contributes to diverse cellular processes. Its structural components include actin-binding domains which allow interaction with the cytoskeleton and other signaling molecules.

Biological function summary

EPS8L2 regulates actin cytoskeleton dynamics and signal transduction pathways. It is part of the EPS8 family of proteins and functions within a complex to mediate cell shape and movement. This protein acts as a scaffold that facilitates interactions among actin filaments and other proteins which influences cell migration and invasion. EPS8L2 modifies actin-related changes that are essential in dynamic cellular environments.

Pathways

EPS8L2 integrates into the EGFR (Epidermal Growth Factor Receptor) signaling pathway influencing cellular growth and differentiation. In another role it participates in the MAPK/ERK pathway by interacting with components like GRB2 and SOS1. These pathways control various aspects of cell behavior impacting cell proliferation and survival. Related proteins such as EPS8 also share similar pathway interactions and have overlapping functions in cellular signaling.

Associated diseases and disorders

EPS8L2 connects to cancer and neurodegenerative diseases. In cancer dysregulation of EGFR signaling involving EPS8L2 may contribute to tumor progression and metastasis. The protein's interactions influence cellular behaviors critical to cancer development. In neurodegenerative disorders alterations in cytoskeletal dynamics associated with EPS8L2 may exacerbate conditions like Alzheimer's Disease. This protein interacts with others like ApoE impacting pathways linked to neuronal health and degeneration.

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1 product image

  • Western blot - Anti-EPS8L2 antibody (ab126155), expandable thumbnail

    Western blot - Anti-EPS8L2 antibody (ab126155)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-EPS8L2 antibody (ab126155) at 1/1000 dilution

    Lane 1: A431 whole cell lysate at 30 µg

    Lane 2: HepG2 whole cell lysate at 30 µg

    Predicted band size: 81 kDa

Downloads

Product protocols

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