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AB233036

Anti-EPSTI1 antibody

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(2 Publications)

Rabbit Polyclonal EPSTI1 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EPSTI1 aa 50-300.

View Alternative Names

Epithelial-stromal interaction protein 1, EPSTI1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPSTI1 antibody (AB233036)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPSTI1 antibody (AB233036)

Formalin-fixed, paraffin-embedded human kidney tissue stained for EPSTI1 using ab233036 at 20 μg/mL in immunohistochemical analysis. DAB staining.

Western blot - Anti-EPSTI1 antibody (AB233036)
  • WB

Supplier Data

Western blot - Anti-EPSTI1 antibody (AB233036)

All lanes:

Western blot - Anti-EPSTI1 antibody (ab233036) at 2 µg/mL

All lanes:

Recombinant human EPSTI1 protein

Predicted band size: 37 kDa

false

Western blot - Anti-EPSTI1 antibody (AB233036)
  • WB

Supplier Data

Western blot - Anti-EPSTI1 antibody (AB233036)

All lanes:

Western blot - Anti-EPSTI1 antibody (ab233036) at 2 µg/mL

All lanes:

MCF7 (human breast adenocarcinoma cell line) cell lysate

Predicted band size: 37 kDa

false

Western blot - Anti-EPSTI1 antibody (AB233036)
  • WB

Supplier Data

Western blot - Anti-EPSTI1 antibody (AB233036)

All lanes:

Western blot - Anti-EPSTI1 antibody (ab233036) at 2 µg/mL

All lanes:

Pig small intestine lysate

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human EPSTI1 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

Q96J88

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EPSTI1 also known as epithelial stromal interaction 1 is a protein involved in cellular interactions particularly between stromal and epithelial cells. It has a molecular mass of approximately 41 kDa. Humans express EPSTI1 in various tissues with higher levels detected in organs like the placenta lung and immune cells such as macrophages. This distribution suggests that EPSTI1 might play a multifaceted role in tissue homeostasis and immune responses.
Biological function summary

EPSTI1 contributes to cellular processes including cell differentiation immune response modulation and signaling pathways that mediate cell-cell communication. While it is not part of a well-defined protein complex it often associates with proteins involved in transcription regulation and immune signaling cascades. These associations imply that EPSTI1 might regulate gene expression patterns impacting cell behavior.

Pathways

EPSTI1 features prominently in immune and cancer-related signaling. It interacts with pathways such as the interferon response and NF-kB pathway. EPSTI1 affects transcription factors and signaling proteins including STAT1 and STAT3 which play critical roles in mediating immune responses and promoting oncogenesis. EPSTI1's interaction with these pathways highlights its involvement in cellular stress responses and inflammation.

EPSTI1 has links to cancer and autoimmune diseases. Overexpression of EPSTI1 frequently occurs in breast cancer suggesting a role in tumor progression and metastasis. In autoimmune conditions like systemic lupus erythematosus EPSTI1 may alter immune system regulation contributing to chronic inflammation. EPSTI1's interaction with proteins such as STAT1 might drive these pathogenic processes linking the protein to disease etiology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity).
See full target information EPSTI1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic surgery and research 18:220 PubMed36941600

2023

Circ_0000479 promotes proliferation, invasion, migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes via miR-766/FKBP5 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Zhao,Guobin Ma,Lintong Ma

Nature communications 12:6845 PubMed34824246

2021

Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Ting Chen,Qi-Yuan Yang,Yun Hu,Xiang-Dong Liu,Jeanene M de Avila,Mei-Jun Zhu,Peter W Nathanielsz,Min Du
View all publications
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