Mouse Monoclonal EPX antibody. Suitable for Flow Cyt, ICC/IF, IHC-Fr and reacts with Human samples. Immunogen corresponding to Cell preparation containing EPX protein.
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA
| Flow Cyt | ICC/IF | IHC-Fr | |
|---|---|---|---|
| Human | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes 30 mins room temperature. |
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Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
EPER, EPO, EPP, EPX, Eosinophil peroxidase
Mouse Monoclonal EPX antibody. Suitable for Flow Cyt, ICC/IF, IHC-Fr and reacts with Human samples. Immunogen corresponding to Cell preparation containing EPX protein.
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA
purified from Bioreactor Concentrates
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EPX also known as eosinophil peroxidase or e p x is an enzyme with a molecular mass of approximately 71 kDa. This enzyme is mainly expressed in eosinophils a type of white blood cell involved in the immune response. EPX is located in the granules of eosinophils and it plays a role in the catalysis of halide ions and hydrogen peroxide to produce hypohalous acids which are potent antimicrobial agents. These acids contribute to the killing of bacteria and other pathogens making the enzyme a critical component of the immune system.
Eosinophil peroxidase participates in the body's defense against parasitic infections and allergic reactions. It is not known to be a part of a larger protein complex but it does interact with other proteins within the immune response setting. EPX helps in generating reactive oxygen species which have antimicrobial properties and are important in immune signaling pathways. Although it can lead to tissue damage when overproduced its controlled activity is necessary for effective immune function.
Eosinophil peroxidase's activity intersects with the respiratory burst pathway and the detoxification pathway. The enzyme contributes to the formation of reactive oxygen species in the respiratory burst pathway which is important for pathogen destruction. EPX is also connected with enzymes like myeloperoxidase (MPO) that function similarly in the immune response though EPX is more specific to eosinophils. This specialization makes it an important player in eosinophil-associated diseases and disorders.
Eosinophil peroxidase has links to asthma and allergic diseases. Its activity in producing reactive oxygen species and hypohalous acids can exacerbate airway inflammation in asthma resulting in tissue damage. Additionally EPX has been studied in the context of autoimmune conditions as its dysregulated activity may contribute to inflammation. Its interaction with other proteins like myeloperoxidase could also influence such diseases highlighting the enzyme's role in pathological processes beyond its beneficial antimicrobial functions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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