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AB242088

Anti-Erasin antibody

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(1 Publication)

Rabbit Polyclonal Erasin antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human UBXN4 aa 450 to C-terminus.

View Alternative Names

KIAA0242, UBXD2, UBXDC1, UBXN4, UBX domain-containing protein 4, Erasin, UBX domain-containing protein 2

1 Images
Immunoprecipitation - Anti-Erasin antibody (AB242088)
  • IP

Supplier Data

Immunoprecipitation - Anti-Erasin antibody (AB242088)

Erasin was immunoprecipitated from HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab242088 at 8 μl/reaction. Western blot was performed from the immunoprecipitate using ab242088 at 1/4000 dilution.

Lane 1 : ab242088 IP in HEK-293T whole cell lysate.
Lane 2 : Control IgG IP in HEK-293T whole cell lysate.

Detection : Chemiluminescence with exposure time of 30 seconds.

Lysates prepared in NETN buffer.

All lanes:

Immunoprecipitation - Anti-Erasin antibody (ab242088)

Predicted band size: 57 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human UBXN4 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q92575

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p>8 - 15 μl/mg lysate</p>" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antibody was affinity purified using an epitope specific to Erasin immobilized on solid support.
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Erasin also known as X15H8 protein is a cellular protein with a mass of approximately 54 kDa. It functions as a molecular chaperone by helping in the folding and assembly of nascent polypeptides into functional proteins. Erasin is expressed mostly in liver and kidney tissues but can also be found in smaller amounts in other organs. This expression pattern supports its involvement in maintaining protein homeostasis and cellular proteostasis mechanisms in metabolically active tissues.
Biological function summary

The roles of Erasin extend beyond its chaperone activities. It is a component of a larger proteostasis network interacting with other cellular machineries to regulate degradation processes. Erasin helps in stabilizing misfolded proteins and prevents aggregation which could be harmful to the cell. Its presence in the endoplasmic reticulum signifies its function in protein quality control and stress response especially under conditions that challenge cellular homeostasis.

Pathways

Erasin actively participates in the unfolded protein response (UPR) and ER-associated degradation (ERAD) pathways. These pathways are important for eliminating defective proteins and maintaining cellular equilibrium. Erasin interacts closely with Bip and Calnexin both of which are key players in the ER stress response. By aiding these networks Erasin contributes to cellular health by ensuring that proteins achieve and maintain their correct structures.

Erasin engages in conditions related to protein misfolding and aggregation. Alzheimer's disease and cystic fibrosis are two such disorders where proteostasis is disrupted. In Alzheimer's disease the accumulation of misfolded amyloid-beta peptides links back to Erasin's role in protein folding and clearance. Similarly Erasin's interaction with DeltaF508-CFTR highlights its involvement in cystic fibrosis where proper folding of the CFTR protein is impaired. These associations highlight the pivotal role of Erasin in conditions that challenge cellular protein management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed : 19822669).
See full target information UBXN4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 23:3 PubMed34815755

2021

Hirudin, a thrombin inhibitor, attenuates TGF-β-induced fibrosis in renal proximal tubular epithelial cells by inhibition of protease-activated receptor 1 expression via S1P/S1PR2/S1PR3 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Lin,Chunli Long,Zhengang Wang,Ronghui Wang,Wei Shi,Jiwei Qiu,Junlin Mo,Yongxiang Xie
View all publications
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Product promise

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