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AB233512

Anti-EREG antibody

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(5 Publications)

Rabbit Polyclonal Epiregulin antibody. Suitable for WB and reacts with Human, Recombinant full length protein - Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Proepiregulin aa 1 to C-terminus.

View Alternative Names

Proepiregulin, EREG

2 Images
Western blot - Anti-EREG antibody (AB233512)
  • WB

Supplier Data

Western blot - Anti-EREG antibody (AB233512)

All lanes:

Western blot - Anti-EREG antibody (ab233512) at 2 µg/mL

Lane 1:

Human placenta tissue lysate

Lane 2:

Human lymphocyte cell lysate

Lane 3:

Mouse lymphocyte cell lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 19 kDa

false

Western blot - Anti-EREG antibody (AB233512)
  • WB

Supplier Data

Western blot - Anti-EREG antibody (AB233512)

All lanes:

Western blot - Anti-EREG antibody (ab233512) at 2 µg/mL

All lanes:

Recombinant human EREG protein

Predicted band size: 19 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human Proepiregulin aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O14944

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The EREG protein also known as epiregulin is part of the epidermal growth factor (EGF) family. It is a small polypeptide with a molecular weight of approximately 19 kDa. EREG is expressed in various tissues including the liver kidney and colon. It interacts with EGF receptors (EGFR) activating them through dimerization which then triggers downstream signaling processes.
Biological function summary

Epiregulin plays a significant role in cell proliferation migration and differentiation. It is not part of a larger complex but functions by binding to EGFR to exert its effects. Its interaction with EGFR influences numerous cellular processes important for tissue repair and development making EREG an important player in physiological and pathological conditions.

Pathways

Epiregulin is tied into the EGFR signaling pathway and the MAPK pathway. It works together with other growth factors like transforming growth factor-alpha (TGF-α) in these pathways. Through EGFR activation EREG influences cellular responses that are critical for growth and survival linking it to broader biological functions involving MAPK signaling cascades.

Epiregulin links to cancer progression and inflammatory diseases. In some cancers EREG overexpression correlates with aggressive tumor growth and poor prognosis. In inflammatory conditions it can modulate responses impacting diseases such as psoriasis by interacting with proteins like EGFR. Understanding EREG's roles provides insights into therapeutic strategies targeting EGFR-related pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed : 9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed : 24631357).
See full target information Proepiregulin
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 25:1417 PubMed40898094

2025

KRAS mutation promotes immune escape of lung adenocarcinoma via ZNF24/SLC7A5/PD-L1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Leilei Li,Qiang Feng,Ya Jiang,Lilin Yang,Hong Fang,Wenmang Xu,Yuanyuan Wang,Xinyan Pan,Julun Yang

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2402299 PubMed39316370

2024

Embryo-Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Yuan Li,Ying Wu,Hao-Lan Tang,Ying Wang,Bo Li,Yu-Ying He,Gui-Jun Yan,Zeng-Ming Yang

The EMBO journal 43:1388-1419 PubMed38514807

2024

The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex.

Applications

Unspecified application

Species

Unspecified reactive species

Paula Cubillos,Nora Ditzer,Annika Kolodziejczyk,Gustav Schwenk,Janine Hoffmann,Theresa M Schütze,Razvan P Derihaci,Cahit Birdir,Johannes Em Köllner,Andreas Petzold,Mihail Sarov,Ulrich Martin,Katherine R Long,Pauline Wimberger,Mareike Albert

International journal of biological sciences 20:818-830 PubMed38250159

2024

IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chiao-Wen Lin,Wei-En Yang,Chun-Wen Su,Hsueh-Ju Lu,Shih-Chi Su,Shun-Fa Yang

American journal of cancer research 12:2492-2525 PubMed35812040

2022

The homeostatic malfunction of a novel feedback pathway formed by lncRNA021545, miR-330-3p and epiregulin contributes in hepatocarcinoma progression via mediating epithelial-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Siwen Yang,Yunkun Zhang,Chunmei Guo,Rui Liu,Maroua Elkharti,Zhenhua Ge,Qinlong Liu,Shuqing Liu,Ming-Zhong Sun
View all publications
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