Anti-ERF antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ERF or Ets2 repressor factor is a transcription factor that regulates gene expression by binding to specific DNA sequences. Sometimes referred to as ERF2 this protein has a molecular mass of around 54 kDa. ERF is widely expressed in various tissues including the liver lungs and brain. It localizes mainly in the nucleus where it interacts with DNA to modulate transcriptional activities influencing cellular responses.

Biological function summary

Ets2 repressor factor plays a role in growth regulation. It is known to negatively control the activity of other ETS transcription factors restricting their ability to activate gene expression linked with cell proliferation and differentiation. ERF is not usually part of a larger complex but can form interactions with other regulatory molecules to fine-tune cellular processes. By influencing these pathways ERF helps maintain balanced cell growth and prevent uncontrolled division.

Pathways

ERF integrates into the MAPK/ERK signaling pathway influencing cell cycle control and differentiation. This pathway also involves other proteins such as ERK2 and c-Fos which are important for transmitting signals from extracellular stimuli to the nucleus. Additionally ERF is connected to the TGF-beta signaling pathway where it aids in modulating responses to growth factors that are important in developmental processes and cellular homeostasis.

Associated diseases and disorders

ERF has implications in cancer progression and developmental syndromes. Dysregulation of ERF gene expression can contribute to increased cell proliferation and tumor growth linking it to cancer pathways. For instance its interaction with ERK2 in the MAPK/ERK pathway influences oncogenic processes. In developmental syndromes mutations in ERF are associated with craniosynostosis a condition affecting skull development often involving altered signaling pathways related to protein FGFR2 which can result in impaired cell differentiation and growth regulation.