Anti-ERGIC3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The ERGIC3 protein also known as ERGIC-53 plays a critical role in the early secretory pathway. It is involved in vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus. Weighing around 38 kDa ERGIC3 is an important contributor to cargo transport processes. The protein finds expression in various tissues predominantly within cells that have high secretory demands.

Biological function summary

The ERGIC3 protein functions as part of the larger ER-Golgi intermediate compartment (ERGIC) complex helping in the sorting and transport of proteins. The ERGIC serves as an essential hub in the secretory pathway modulating cargo movement to the Golgi for further processing. Some studies have implicated ERGIC3 in maintaining Golgi integrity and optimal function affecting overall cellular health.

Pathways

ERGIC3 plays a significant role in the secretory pathway assisting in the transit of proteins and the correct folding of polypeptides. It links functionally to other key proteins such as KI67 which associates with cell proliferation regions and relies heavily on efficient protein processing for cellular division. The association suggests ERGIC3’s involvement in maintaining cellular growth and regeneration.

Associated diseases and disorders

Researchers have connected ERGIC3 with diseases like congenital disorders of glycosylation due to its role in protein folding and trafficking. Furthermore disruptions in ERGIC3 function have correlations with cancer progression particularly in overactive secretion conditions. These disorders often coincide with aberrant expression or mutations in folding-related proteins signifying potential ERGIC3 involvement in pathological manifestations when its function is compromised.