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AB150936

Anti-Eros antibody

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(1 Publication)

Rabbit Polyclonal Eros antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CYBC1 aa 100-200.
5 Images
Immunocytochemistry/ Immunofluorescence - Anti-Eros antibody (AB150936)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Eros antibody (AB150936)

Immunocytochemical analysis of A431 (Human epidermoid carcinoma cell line) whole cells labeling Eros in the plasma membrane and cell junctions with ab150936 at 2 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eros antibody (AB150936)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eros antibody (AB150936)

Immunohistochemical analysis of human prostate tissue labeling Eros in the membrane of smooth muscle cells with ab150936 at a 1/500 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eros antibody (AB150936)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eros antibody (AB150936)

Immunohistochemical analysis of human colon tissue labeling Eros in the cytoplasm of lymphoid cells with ab150936 at a 1/500 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eros antibody (AB150936)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eros antibody (AB150936)

Immunohistochemical analysis of human placenta tissue labeling Eros in the cytoplasm of trophoblastic cells with ab150936 at a 1/500 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eros antibody (AB150936)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Eros antibody (AB150936)

Immunohistochemical analysis of human tonsil tissue labeling Eros in the cytoplasm of non-germinal center cells with ab150936 at a 1/500 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CYBC1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9BQA9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The biological target known as Eros also referred to as 'peptides’ or 'anti Eros' is a protein associated with various cellular functions. Eros has a molecular mass typically around 30 kDa. It is expressed in multiple tissues prominently in the cells of the immune system. This protein modulates immune responses and cell signaling. The distribution of Eros is essential for effective cellular defense mechanisms.
Biological function summary

The function of Eros extends beyond simple protein interactions. It contributes significantly to reactive oxygen species (ROS) production which is important in phagocytic processes. Eros acts as part of the NADPH oxidase complex a multi-component enzyme system found within phagocytes. The assembly of this complex remains fundamental for generating ROS facilitating microbial killing during immune defenses and inflammation.

Pathways

Eros operates intricately within the immune response modulation and redox regulation pathways. It plays an important role in the oxidative burst pathway where its presence is necessary for proper NADPH oxidase function. This involves interactions with protein components such as gp91phox and p22phox which are part of the membrane-bound cytochrome b558. Eros helps to maintain optimal activity of this complex ensuring effective pathogen destruction.

Eros is linked with chronic granulomatous disease (CGD) and inflammatory response dysregulation. Deficient Eros function can lead to CGD a condition caused by an inability to produce sufficient ROS for microbial destruction. This connection highlights the relationships between Eros and other components of the NADPH oxidase complex including p47phox which also suffers mutations in CGD. Dysfunctional Eros may also contribute to inflammatory disorders potentially influencing disease progression and severity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (PubMed : 30361506). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity).
See full target information CYBC1

Alternative Names

C17orf62, EROS, CYBC1, Cytochrome b-245 chaperone 1, Essential for reactive oxygen species protein, Eros
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Journal of virology 90:3173-86 PubMed26739050

2016

Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication.

Applications

Unspecified application

Species

Unspecified reactive species

Yuka Sato,Akihisa Kato,Yuhei Maruzuru,Masaaki Oyama,Hiroko Kozuka-Hata,Jun Arii,Yasushi Kawaguchi
View all publications
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Product promise

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