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AB82587

Anti-ERp72 antibody

5

(2 Reviews)

|

(5 Publications)

Rabbit Polyclonal ERp72 antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Mouse Pdia4 aa 600 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Cai, Erp72, Protein disulfide-isomerase A4, Endoplasmic reticulum resident protein 72, ER protein 72, ERp-72, ERp72

1 Images
Western blot - Anti-ERp72 antibody (AB82587)
  • WB

Unknown

Western blot - Anti-ERp72 antibody (AB82587)

All lanes:

Western blot - Anti-ERp72 antibody (ab82587) at 1/1000 dilution

Lane 1:

Rat liver microsome extract

Lane 2:

Mouse liver microsome extract

Lane 3:

Human liver microsome extract

Predicted band size: 73 kDa

Observed band size: 73 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Mouse Pdia4 aa 600 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P08003

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ERp72 also known as PDIA4 is a protein with a molecular weight of approximately 72 kDa. It belongs to the protein disulfide isomerase (PDI) family and functions as an enzyme within the endoplasmic reticulum (ER). The protein helps with folding by catalyzing the formation rearrangement and breakage of disulfide bonds in nascent proteins. ERp72 is expressed in a variety of tissues with high abundance in the liver pancreas and other secretory organs reflecting its role in protein synthesis and processing.
Biological function summary

The protein disulfide isomerase family member ERp72 plays a significant part in maintaining ER function. It participates in the unfolded protein response (UPR) which ensures proper protein folding and manages ER stress. ERp72 operates as part of a larger multiprotein complex that aids in the quality control of newly synthesized proteins. The protein interacts with calnexin and BiP to perform these functions. This makes ERp72 essential for cellular homeostasis and adaptation to changing physiological conditions.

Pathways

ERp72 is closely involved in the protein folding and ER stress response pathways. The unfolded protein response pathway recognizes misfolded proteins in the ER and initiates mechanisms to restore normal function. It connects with other proteins such as ATF6 and IRE1 to modulate gene expression and improve protein folding capacity. Additionally ERp72 participates in the pathway related to oxidative protein folding working alongside proteins like ERO1. This confirms its key contribution to cellular function by maintaining the balance between protein folding and degradation.

Alterations in ERp72 expression or function link to conditions such as neurodegenerative diseases and cancer. Alzheimer's disease shows aberrant ER stress and misfolded protein accumulation where ERp72's interaction with amyloid precursor protein might play a role. In the case of cancer ER stress and UPR pathway alterations contribute to cancer cell survival associating ERp72 with this adaptation process particularly its interaction with BiP and other PDIs. These connections highlight the relevance of ERp72 in disease progression and as a potential therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Pdia4
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:2535 PubMed40087276

2025

ER O-glycosylation in synovial fibroblasts drives cartilage degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Le Son Tran,Joanne Chia,Xavier Le Guezennec,Keit Min Tham,Anh Tuan Nguyen,Virginie Sandrin,Way Cherng Chen,Tan Tong Leng,Sreedharan Sechachalam,Khai Pang Leong,Frederic A Bard

Molecular medicine reports 23: PubMed33398381

2021

Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury.

Applications

Unspecified application

Species

Unspecified reactive species

Noureddine Ben Khalaf,Dalal Al-Μehatab,Dahmani M Fathallah

Molecular medicine reports 22:697-706 PubMed32626931

2020

Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Song,Wenbo Ding,Bojia Liu,Dan Liu,Zhi Xia,Li Zhang,Li Cui,Yi Luo,Xiaobin Jia,Liang Feng

Redox biology 22:101142 PubMed30870787

2019

Protein disulfide isomerase plasma levels in healthy humans reveal proteomic signatures involved in contrasting endothelial phenotypes.

Applications

Unspecified application

Species

Unspecified reactive species

Percíllia Victória Santos de Oliveira,Sheila Garcia-Rosa,Ana Teresa Azevedo Sachetto,Ana Iochabel Soares Moretti,Victor Debbas,Tiphany Coralie De Bessa,Nathalia Tenguan Silva,Alexandre da Costa Pereira,Daniel Martins-de-Souza,Marcelo Larami Santoro,Francisco Rafael Martins Laurindo

Nature 528:510-6 PubMed26618866

2015

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra Pankow,Casimir Bamberger,Diego Calzolari,Salvador Martínez-Bartolomé,Mathieu Lavallée-Adam,William E Balch,John R Yates
View all publications
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Product promise

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