Anti-ESAT-6-like protein EsxR antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

EsxR engages in host-pathogen interactions and is essential for the virulence of Mycobacterium tuberculosis. It forms a complex with EsxS another member of the same protein family which is critical for their function. This protein complex contributes to the modulation of the host immune system allowing the bacteria to evade immune responses. In this way EsxR influences the bacterial survival and persistence within host cells.

Pathways

EsxR is significantly involved in the secretion pathways utilized by Mycobacterium tuberculosis. It forms part of the ESX-1 secretion system a Type VII secretion system which is central to transporting proteins across the bacterial cell envelope. Other proteins such as EsxA and EsxB work along with EsxR within this pathway to facilitate secretion processes that interfere with host immune mechanisms. This system aids in the bacterial ability to manipulate host cell's responses and establish infection.