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AB219996

Anti-ESCO2 antibody

5

(1 Review)

|

(1 Publication)

Rabbit Polyclonal ESCO2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ESCO2 aa 300-400.

View Alternative Names

N-acetyltransferase ESCO2, Establishment factor-like protein 2, Establishment of cohesion 1 homolog 2, EFO2, EFO2p, hEFO2, ECO1 homolog 2, ESCO2

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-ESCO2 antibody (AB219996)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ESCO2 antibody (AB219996)

Immunofluorescent analysis of PFA-fixed, triton X-100 permeabilized U-2 OS cells labeling ESCO2 with ab219996 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ESCO2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q56NI9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ESCO2 also known as Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2 is a protein with a mass of about 68 kDa. It is expressed widely across various human tissues with notable presence in proliferating cells. ESCO2 has a mechanistic role in the establishment of sister chromatid cohesion during the S phase of the cell cycle. It works by acetylating the cohesin subunit SMC3 which is essential for proper chromosome segregation during mitosis and meiosis.
Biological function summary

ESCO2 functions as a part of the chromosomal cohesion complex which is necessary for maintaining genome stability. The cohesion complex ensures that sister chromatids remain paired from DNA replication in S phase until anaphase. This complex requires synchronized action of cohesin proteins including STAG2 and RAD21 which work together with ESCO2 to ensure the fidelity of chromosomal transmission. By facilitating proper cohesion ESCO2 prevents aneuploidy which is often incompatible with cell viability.

Pathways

The protein ESCO2 interacts with the cell cycle regulatory pathways and chromosomal dynamics. Within these pathways ESCO2 cooperates with proteins like CDK1 and PLK1. These interactions help drive critical transitions between various phases of the cell cycle primarily assuring that chromosomes align correctly and segregate during mitosis. As ESCO2 modifies SMC3 via acetylation this modification is important for the action of the cohesin complex allowing it to perform its functions within the cell cycle control mechanisms.

ESCO2 has significant implications in Roberts Syndrome and certain cancers. Roberts Syndrome a developmental disorder results from mutations in the ESCO2 gene leading to defective cohesion. This defect impacts cell proliferation and differentiation contributing to the syndrome's phenotypic features. In cancer biology abnormal ESCO2 expression or function can result in genomic instability promoting oncogenesis. The interplay of ESCO2 with cohesin proteins like SMC3 and STAG2 highlights its critical role in maintaining chromosomal integrity essential for preventing disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed : 15821733, PubMed : 15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed : 21111234).
See full target information ESCO2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell communication and signaling 19:e70037 PubMed40717692

2025

Cancer-associated fibroblasts-secreted lactate promotes RNA polymerase III subunit G-mediated epithelial-mesenchymal transition in non-small cell lung cancer by increasing m6A modification of zinc finger protein 384.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Li,Xing Yang,Hao Tang,Zhiping Zhou,Bin Liu
View all publications
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