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AB214934

Anti-ESGP antibody

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(2 Publications)

Sheep Polyclonal ESGP antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Mymx.

View Alternative Names

Gm7325, Mymx, Protein myomixer, Embryonic stem cell- and germ cell-specific protein, Microprotein inducer of fusion, Protein myomerger, ESGP, Protein minion

1 Images
Western blot - Anti-ESGP antibody (AB214934)
  • WB

Supplier Data

Western blot - Anti-ESGP antibody (AB214934)

All lanes:

Western blot - Anti-ESGP antibody (ab214934) at 1/1000 dilution

All lanes:

Mouse embryonic tissue lysate

Predicted band size: 10 kDa

Observed band size: 12 kDa

false

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Mymx.

Q2Q5T5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
The IgG fraction of immunized serum was purified by antigen affinity chromatography.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ESGP protein short for Epithelial Sodium-Gated Protein serves as an important regulator in ion transport across epithelial cells. This protein approximately 90 kDa in molecular weight mainly expresses in the epithelial tissues of kidneys lungs and intestines. Alternative names for ESGP include ENaC (Epithelial Sodium Channel) and γ-ENaC which highlight its role as a subunit of the larger epithelial sodium channel complex.
Biological function summary

ESGP plays an integral role in the regulation of sodium balance impacting both fluid volume and blood pressure. As a part of the ENaC complex its activity in absorbing sodium ions from the lumen of epithelial surfaces significantly affects electrolyte homeostasis. Disregulation of ESGP function can cause a cascade of imbalances signaling its importance in maintaining cellular and systemic equilibrium.

Pathways

ESGP is pivotal in the renin-angiotensin-aldosterone system (RAAS) and the regulation of blood pressure pathways. In the RAAS pathway the ESGP associates with proteins like aldosterone-induced proteins to modulate sodium reabsorption. It also ties to proteins such as NEDD4 which influence its ubiquitination and therefore its activity within the pathway. This interaction demonstrates its central role in fluid regulation pathways.

ESGP has associations with conditions such as Liddle syndrome and cystic fibrosis. Liddle syndrome results from mutations that heighten the activity of ESGP leading to increased sodium retention and resulting hypertension. In cystic fibrosis aberrations in ESGP function contribute to abnormal salt transport across epithelial cells. In these conditions ESGP closely interacts with CFTR and other channel proteins that modulate ion transport highlighting its importance in maintaining ionic balance and disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed : 28386024, PubMed : 28569745, PubMed : 28569755, PubMed : 30197239). Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK (PubMed : 30197239). Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation (PubMed : 30197239). Acts independently of MYMK (PubMed : 30197239). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (PubMed : 29581287).
See full target information Mymx
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:33948 PubMed41028869

2025

Impaired myogenesis in limb girdle muscular dystrophy type 2B.

Applications

Unspecified application

Species

Unspecified reactive species

Lucas Santos Souza,Renata Ishiba,Antonio Fernando Ribeiro-Junior,Isabela Aquino Zogbi,Dounia Bouragba,Anne Bigot,Vincent Mouly,Mariz Vainzof

Cell reports 30:510-524.e6 PubMed31940493

2020

FOXD3 Regulates VISTA Expression in Melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Sheera R Rosenbaum,Meghan Knecht,Mehri Mollaee,Zhijiu Zhong,Dan A Erkes,Peter A McCue,Inna Chervoneva,Adam C Berger,Jennifer A Lo,David E Fisher,Jeffrey E Gershenwald,Michael A Davies,Timothy J Purwin,Andrew E Aplin
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