AB103590

Anti-ESM1 antibody

Name: Anti-ESM1 antibody. Rabbit polyclonal (ab103590) | Abcam
Brand: Abcam Limited
SKU: AB103590
Price: 455 USD
Availability: InStock
Rating: 4 (3 reviews)

(3 Reviews)

(31 Publications)

Rabbit Polyclonal ESM1 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human, Mouse samples. Cited in 31 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Endothelial cell-specific molecule 1.

View Alternative Names

Endothelial cell-specific molecule 1, ESM-1, ESM1

1 Images

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Western blot - Anti-ESM1 antibody (AB103590)

All lanes:

Western blot - Anti-ESM1 antibody (ab103590) at 1/500 dilution

All lanes:

Human kidney tissue lysate at 50 µg

Predicted band size: 20 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human, Mouse

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Endothelial cell-specific molecule 1.

Q9NQ30

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Endothelial cell-specific molecule 1 (ESM1) also known as endocan is a proteoglycan with a mass of approximately 50 kDa. It is primarily expressed in endothelial cells of blood vessels particularly in the lungs and the kidneys. ESM1 consists of a core protein covalently attached to dermatan sulfate chains. Its expression often increases under inflammatory conditions which highlights its role in vascular biology.

Biological function summary

ESM1 acts in the regulation of cell adhesion and migration processes. It interacts with leukocytes and participates in modulating inflammatory responses. ESM1 does not form part of a multi-protein complex but its activity can influence the behavior of other cell surface molecules and receptors. This function positions ESM1 as a critical player in the dynamics of vascular endothelium.

Pathways

ESM1 modulates inflammation and angiogenesis by participating in pathways involving vascular endothelial growth factor (VEGF). It interacts with proteins such as VEGF receptor-2 impacting endothelial permeability and new blood vessel formation. These interactions situate ESM1 within the signaling networks that regulate endothelial function and vascular homeostasis.

Research associates ESM1 with conditions such as sepsis and cancer. High levels of this molecule correlate with poor prognosis in these diseases linking it functionally to VEGF and other factors involved in abnormal endothelial cell activity. Understanding ESM1's role provides insights into mechanisms of disease progression and potential therapeutic targets.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

See full target information Endothelial cell-specific molecule 1

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Publications (31)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:15572 PubMed40320451

2025

Unveiling the protective role of ESM1 in endothelial cell proliferation and lipid reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Yukun Li,Anbo Gao,Wenchao Zhou,Xing Tang,Tian Zeng,Tingyu Fan,Weimin Jiang,Min Tang,Fan Ouyang

Cell death & disease 16:308 PubMed40240362

2025

IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Anbo Gao,Juan Zou,Tian Zeng,Mei Qin,Xing Tang,Ting Yi,Guangming Song,Jie Zhong,Yuhuan Zeng,Wenchao Zhou,Qin Gao,Qunfeng Zhang,Juan Zhang,Yukun Li

Scientific reports 15:4902 PubMed39929852

2025

ESM1 promote proliferation, invasion and angiogenesis via Akt/mTOR and Ras pathway in kidney renal clear cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjun Luo,Ting Yi,Yong Wang,Wei Song,Zhiyong Gao,Jiansong Wang,Yukun Li

Heliyon 10:e36897 PubMed39281564

2024

The role of ESM1 in the lipids metabolic reprogramming and angiogenesis of lung adenocarcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wenchang Feng,Yi Ting,Xing Tang,Dan Liu,Wen-Chao Zhou,Yukun Li,Zhenyu Shen

Cellular and molecular life sciences : CMLS 81:365 PubMed39172168

2024

Endothelial cell heterogeneity in colorectal cancer: tip cells drive angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenyu Xie,Liaoran Niu,Kunli Du,Ling Chen,Gaozan Zheng,Songchen Dai,Hanjun Dan,Lili Duan,Xinyu Dou,Fan Feng,Jian Zhang,Jianyong Zheng

Endocrine journal 71:789-797 PubMed38945931

2024

Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters.

Applications

Unspecified application

Species

Unspecified reactive species

Melia Karaköse,Mustafa Can,Muhammet Kocabaş,Hacı Hasan Esen,Mustafa Kulaksızoğlu,Feridun Karakurt

International journal of general medicine 17:2809-2820 PubMed38912330

2024

ESM1 May Be Used as a New Indicator for the Diagnosis and Prognosis of Early and Advanced Stage Digestive Tract Cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Kui Kang,Ying Wang,Bo Zhang,Zhengxing Xie,Sheng Qing,Yanan Di

Molecular cancer 23:94 PubMed38720298

2024

ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Zhang,Fan Ouyang,Anbo Gao,Tian Zeng,Ming Li,Hui Li,Wenchao Zhou,Qing Gao,Xing Tang,Qunfeng Zhang,Xiaomin Ran,Gang Tian,Xiyun Quan,Zhenzi Tang,Juan Zou,Yifei Zeng,Yunzhu Long,Yukun Li

PloS one 19:e0298631 PubMed38626010

2024

Functional analysis of ESM1 by shRNA-mediated knockdown of its expression in papillary thyroid cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Lijun Xie,Limeng He,Wei Zhang,Hao Wang

Journal of translational medicine 22:46 PubMed38212795

2024

ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Kun Li,An-Bo Gao,Tian Zeng,Dan Liu,Qun-Feng Zhang,Xiao-Min Ran,Zhen-Zi Tang,Yan Li,Jue Liu,Ting Zhang,Gang-Qing Shi,Wen-Chao Zhou,Wen-da Zou,Juan Peng,Juan Zhang,Hui Li,Juan Zou

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ESM1 antibody

Western blot - Anti-ESM1 antibody (AB103590)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (31)

Product promise