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AB116648

Anti-Estradiol antibody [AB4.2]

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(1 Publication)

Mouse Monoclonal Estradiol antibody. Suitable for IP, ELISA, RIA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Estradiol.

View Alternative Names

17鑴 estradiol, E2, Ethynyl Estradiol, Oestradiol

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

AB4.2

Isotype

IgG1

Carrier free

No

Applications

ELISA, IP, RIA

applications

Specificity

ab116648 shows reactivity with Chemical samples.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Ion exchange chromatography DEAE-C
Storage buffer
Preservative: 0.05% Sodium azide Constituents: 0.79% Sodium chloride, 0.135% Tripotassium orthophosphate, 0.1% BSA, 0.019% Potassium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estradiol also known as E2 is a form of estrogen a steroidal hormone and an important player in the reproductive system. Its molecular mass is approximately 272.4 g/mol. Estradiol is mainly expressed in the ovaries but it is also produced in smaller amounts by fat tissue brain and adrenal glands. It acts as a primary female sex hormone binding to estrogen receptors within target tissues to exert its effects.
Biological function summary

Estradiol plays essential roles in regulating the reproductive and menstrual cycles promoting development and maintenance of female secondary sexual characteristics. The hormone functions as part of a larger complex the estrogen receptor complex which alters gene expression after binding. Beyond reproduction estradiol impacts several systems including skeletal cardiovascular and central nervous systems highlighting its diverse biological roles.

Pathways

This hormone functions in the estrogen signaling pathway and the regulation of gene expression. Estradiol interacts with proteins like estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) to influence various gene expression paths. These pathways govern cell proliferation differentiation and apoptosis highlighting the hormone's intricate involvement in cellular processes and its impact on health and disease.

Estradiol levels influence conditions like breast cancer and osteoporosis. Abnormal estradiol production or receptor dysfunction can contribute to estrogen-dependent breast cancer where high levels promote tumor growth by interacting with proteins like ERα. In osteoporosis estradiol deficiencies accelerate bone resorption by the regulation of osteoclast activity illustrating its important role in maintaining bone health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Estradiol
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of 116:8966-8974 PubMed30962381

2019

Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen.

Applications

Unspecified application

Species

Unspecified reactive species

Peter E Deak,Baksun Kim,Amina Abdul Qayum,Jaeho Shin,Girish Vitalpur,Kirsten M Kloepfer,Matthew J Turner,Neal Smith,Wayne G Shreffler,Tanyel Kiziltepe,Mark H Kaplan,Basar Bilgicer
View all publications
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Product promise

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