Rabbit Polyclonal Estrogen-induced gene 121 protein antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human ELAPOR1 conjugated to Keyhole Limpet Haemocyanin.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ELAPOR1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q6UXG2
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 15 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target data
Function
May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166).
Alternative names
EIG121, KIAA1324, UNQ2426/PRO4985, ELAPOR1, Endosome/lysosome-associated apoptosis and autophagy regulator 1, Estrogen-induced gene 121 protein
Recommended products
Rabbit Polyclonal Estrogen-induced gene 121 protein antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human ELAPOR1 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ELAPOR1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q6UXG2
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Estrogen-induced gene 121 protein also known as EIG121 or KIAA1324 is a protein encoded by the KIAA1324 gene. This protein has a molecular mass of approximately 103 kDa. EIG121 shows expression primarily in tissues responsive to estrogen such as the endometrium and breast tissues. On a subcellular level EIG121 localizes to the endoplasmic reticulum and the cytoplasm suggesting roles in protein processing and trafficking.
- Biological function summary
The EIG121 protein contributes to cellular processes related to growth and differentiation particularly in hormone-responsive tissues. EIG121 does not typically function as part of a larger complex but it is involved in processes sensitive to hormonal regulation. It influences cellular apoptosis and proliferation linked to estrogen signaling. Its function is relevant to maintaining normal tissue homeostasis and it may play roles in modulating the response to environmental estrogenic stimuli.
- Pathways
EIG121 operates within the estrogen signaling pathway influencing cellular responses to hormonal cues. It interacts with components of the apoptosis pathway affecting cell survival mechanisms. Connections exist between EIG121 and proteins like BCL-2 which regulates apoptosis and ERα (estrogen receptor alpha) which mediates estrogen signaling. These interactions integrate EIG121 into critical regulatory networks impacting cell fate decisions.
- Associated diseases and disorders
EIG121 emerges as significant in the context of endometrial cancer and breast cancer. Alterations in its expression levels correlate with cancer progression likely due to its role in estrogen signaling and apoptotic modulation. In breast cancer it associates with ERα influencing cancer cell proliferation in hormone-dependent cancers. In endometrial cancer EIG121's relationship to BCL-2 presents potential implications for cancer cell survival positioning it as a target in therapeutic strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen-induced gene 121 protein antibody (ab133374)
ab133374 (15 ug/mL) was used in IHC to stain formalin-fixed, paraffin-embedded human liver, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen-induced gene 121 protein antibody (ab133374)
(ab133374 15 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human adrenal, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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