AB190942

Anti-Estrogen Inducible Protein pS2 antibody

Name: Anti-Estrogen Inducible Protein pS2 antibody (ab190942) | Abcam
Brand: Abcam Limited
SKU: AB190942
Price: 535 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal Estrogen Inducible Protein pS2 antibody. Suitable for IHC-P, WB and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Mouse Tff1 aa 50 to C-terminus.

View Alternative Names

Ps2, Tff1, Trefoil factor 1, Protein pS2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

Immunohistochemical analysis of paraffin-embedded Rat intestine tissue labeling Estrogen Inducible Protein pS2 with ab190942 at 1 μg/ml.

Supplier Data

Western blot - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

All lanes:

Western blot - Anti-Estrogen Inducible Protein pS2 antibody (ab190942) at 0.5 µg/mL

All lanes:

Rat stomach tissue lysate

Predicted band size: 9 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Mouse Tff1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q08423

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Estrogen Inducible Protein pS2 also known as Trefoil Factor 1 (TFF1) is a small protein with a mass of about 6.6 kDa. It is mainly expressed in the mucosa of the stomach and other tissues responsive to estrogen. pS2 functions mechanically as part of the trefoil factor family known for its role in mucosal protection and repair. pS2 has a distinctive three-loop structure which is key to its interaction with other molecules and substrates in the cellular environment.

Biological function summary

This trefoil factor plays a significant role in the process of epithelial regeneration and maintaining gastrointestinal tract integrity. It is not known to be part of a complex but works through interaction with various growth factors and cytokines. Its expression is regulated by estrogen making pS2 significant in estrogen-responsive tissues. These interactions contribute to maintaining the stability of epithelial lining aiding in cellular migration and wound healing.

Pathways

PS2 influences cellular signaling involved in the gastric mucosal defense mainly interacting with the Epidermal Growth Factor (EGF) pathway. It modulates the pathway's effects on cell proliferation and migration. Its role is linked to the mitigation of tissue damage indicating a connection with other proteins like the EGF receptor contributing to the repair and defense mechanisms of epithelial tissues.

PS2 has gained attention in breast cancer research. Its expression correlates with hormone receptor-positive breast cancer making it a potential biomarker for the disease. Additionally aberrant expression levels of pS2 might relate to gastric cancer where it plays a role in tumor progression and response to therapy. pS2 is closely connected to estrogen receptor proteins which guide its involvement in these cancers influencing prognosis and treatment strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.

See full target information Tff1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 11:4516 PubMed32908137

2020

Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity.

Applications

Unspecified application

Species

Unspecified reactive species

Yehuda Schlesinger,Oshri Yosefov-Levi,Dror Kolodkin-Gal,Roy Zvi Granit,Luriano Peters,Rachel Kalifa,Lei Xia,Abdelmajeed Nasereddin,Idit Shiff,Osher Amran,Yuval Nevo,Sharona Elgavish,Karine Atlan,Gideon Zamir,Oren Parnas

Nature communications 11:2032 PubMed32341344

2020

Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandra Bilska,Monika Kusio-Kobiałka,Paweł S Krawczyk,Olga Gewartowska,Bartosz Tarkowski,Kamil Kobyłecki,Dominika Nowis,Jakub Golab,Jakub Gruchota,Ewa Borsuk,Andrzej Dziembowski,Seweryn Mroczek

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Estrogen Inducible Protein pS2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

Western blot - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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