Rabbit Polyclonal Estrogen Inducible Protein pS2 antibody. Suitable for IHC-P, WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Trefoil factor 1 aa 50 to C-terminus.
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Publications
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- Nature communications 11:45162020Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYehuda Schlesinger et. al.PubMed 32908137
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Mouse Trefoil factor 1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q08423
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Rat | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.50000-1.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.10000-0.50000 µg/mL | Notes - |
Associated Products
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Target data
Function
Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.
Alternative names
Ps2, Tff1, Ps2, Trefoil factor 1, Protein pS2
Recommended products
Rabbit Polyclonal Estrogen Inducible Protein pS2 antibody. Suitable for IHC-P, WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Trefoil factor 1 aa 50 to C-terminus.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Mouse Trefoil factor 1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q08423
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Estrogen Inducible Protein pS2 also known as Trefoil Factor 1 (TFF1) is a small protein with a mass of about 6.6 kDa. It is mainly expressed in the mucosa of the stomach and other tissues responsive to estrogen. pS2 functions mechanically as part of the trefoil factor family known for its role in mucosal protection and repair. pS2 has a distinctive three-loop structure which is key to its interaction with other molecules and substrates in the cellular environment.
- Biological function summary
This trefoil factor plays a significant role in the process of epithelial regeneration and maintaining gastrointestinal tract integrity. It is not known to be part of a complex but works through interaction with various growth factors and cytokines. Its expression is regulated by estrogen making pS2 significant in estrogen-responsive tissues. These interactions contribute to maintaining the stability of epithelial lining aiding in cellular migration and wound healing.
- Pathways
PS2 influences cellular signaling involved in the gastric mucosal defense mainly interacting with the Epidermal Growth Factor (EGF) pathway. It modulates the pathway's effects on cell proliferation and migration. Its role is linked to the mitigation of tissue damage indicating a connection with other proteins like the EGF receptor contributing to the repair and defense mechanisms of epithelial tissues.
- Associated diseases and disorders
PS2 has gained attention in breast cancer research. Its expression correlates with hormone receptor-positive breast cancer making it a potential biomarker for the disease. Additionally aberrant expression levels of pS2 might relate to gastric cancer where it plays a role in tumor progression and response to therapy. pS2 is closely connected to estrogen receptor proteins which guide its involvement in these cancers influencing prognosis and treatment strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Inducible Protein pS2 antibody (ab190942)
Immunohistochemical analysis of paraffin-embedded Rat intestine tissue labeling Estrogen Inducible Protein pS2 with ab190942 at 1 μg/ml.
Western blot - Anti-Estrogen Inducible Protein pS2 antibody (ab190942)
All lanes: Western blot - Anti-Estrogen Inducible Protein pS2 antibody (ab190942) at 0.5 µg/mL
All lanes: Rat stomach tissue lysate
Predicted band size: 9 kDa
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