AB5786

Anti-Estrogen Receptor beta antibody

Name: Anti-Estrogen Receptor beta antibody (ab5786) | Abcam
Brand: Abcam Limited
SKU: AB5786
Price: 525 USD
Availability: InStock

(1 Review)

(9 Publications)

Rabbit Polyclonal ESR2 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human ESR2 aa 450 to C-terminus.

View Alternative Names

ESTRB, NR3A2, ESR2, Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Receptor beta antibody (AB5786)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Receptor beta antibody (AB5786)

Immunohistochemical staining with ab5786 detects nuclear Estrogen Receptor beta in rat prostate

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ESR2 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q92731

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2-5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Receptor beta (ERβ) also known as ERbeta or beta receptor is an important nuclear receptor involved in mediating the effects of estrogens such as estradiol. This receptor with a molecular weight of approximately 59 kDa resides mainly in endothelial and epithelial tissues and can also be present in the central nervous system. ERβ possesses the ability to bind ligands and translocate to the nucleus where it regulates the transcription of specific target genes.

Biological function summary

Estrogen Receptor beta plays a significant role in cell growth regulation and differentiation. It often forms dimers with Estrogen Receptor alpha (ERα) contributing to the diversity of estrogen signaling responses. As part of the nuclear receptor family ERβ engages in binding with DNA at estrogen response elements influencing various physiological processes. The presence of ERβ in tissues implies it has a potentially protective role possibly balancing the actions of ERα.

Pathways

Estrogen Receptor beta plays an essential role in the estrogen signaling pathway and the apoptosis pathway. Interaction with ERα can influence pathways related to cell proliferation and survival contributing to distinct physiological outcomes. ERβ's involvement with proteins like the retinoic acid receptor within these pathways highlights its impact on controlling gene expression important for cell cycle regulation and programmed cell death.

Estrogen Receptor beta has implications in cancers and cardiovascular diseases. In breast cancer ERβ may act differently from ERα possibly providing protective effects against tumor growth. Moreover the receptor's expression affects cardiovascular health by modulating inflammation and vascular function. ERβ interacts with proteins such as p53 hinting at its role in controlling cellular stress responses and combating oncogenesis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed : 20074560).. Isoform 2. Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

See full target information ESR2

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical medicine 14: PubMed40807137

2025

Aromatase Inhibitor-Induced Carpal Tunnel Syndrome Immunohistochemical Analysis and Clinical Evaluation: An Observational, Cross-Sectional, Case-Control Study.

Applications

Unspecified application

Species

Unspecified reactive species

Iakov Molayem,Lucian Lior Marcovici,Roberto Gradini,Massimiliano Mancini,Silvia Taccogna,Alessia Pagnotta

Current stem cell research & therapy 19:725-734 PubMed37448361

2024

Use of Mesenchymal Stem Cells in Experimental Ovarian Damage.

Applications

Unspecified application

Species

Unspecified reactive species

Hanan Fouad,Ibrahim A Albahlol,Hazim A Wahab,Eman H Nadwa,Heba M Galal,Mohamed Abouelkheir,Ahmed E Taha,Abdelkarim G Kamel,Hassan A Abdelmawlla

Journal of clinical ultrasound : JCU 51:195-202 PubMed36539919

2022

Application of dual-source computed tomography in the diagnosis of thyroid cancer and evaluation of biological behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Wenhui Wu,Xuewen Fang,Jianming Li,An Zhang,Yujian Zou,Xiaolin Zheng

International journal of molecular sciences 23: PubMed36499085

2022

Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Datu Agasi Mohd Kamal,Siti Fatimah Ibrahim,Azizah Ugusman,Mohd Helmy Mokhtar

Chinese journal of cancer 36:89 PubMed29122010

2017

Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes.

Applications

IHC-P

Species

Human

Jianhong Peng,Qingjian Ou,Xiaojun Wu,Rongxin Zhang,Qian Zhao,Wu Jiang,Zhenhai Lu,Desen Wan,Zhizhong Pan,Yujing Fang

Biochimica et biophysica acta. Molecular basis of 1863:2808-2820 PubMed28712835

2017

Biological impact of advanced glycation endproducts on estrogen receptor-positive MCF-7 breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sabine Matou-Nasri,Hana Sharaf,Qiuyu Wang,Nasser Almobadel,Zaki Rabhan,Hamad Al-Eidi,Wesam Bin Yahya,Thadeo Trivilegio,Rizwan Ali,Nasser Al-Shanti,Nessar Ahmed

Stem cell research & therapy 8:156 PubMed28676082

2017

Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhui Li,Yan Wen,Morgaine Green,Elise K Cabral,Prachi Wani,Fan Zhang,Yi Wei,Thomas M Baer,Bertha Chen

BMC cancer 14:279 PubMed24755315

2014

Vascular measurements correlate with estrogen receptor status.

Applications

IHC-P

Species

Human

Mark C Lloyd,Khalid O Alfarouk,Daniel Verduzco,Marilyn M Bui,Robert J Gillies,Muntaser E Ibrahim,Joel S Brown,Robert A Gatenby

The British journal of nutrition 102:703-8 PubMed19309532

2009

Effects of a diet rich in sesame ( Sesamum indicum) pericarp on the expression of oestrogen receptor alpha and oestrogen receptor beta in rat prostate and uterus.

Applications

Species

Rat

Aristotelis Anagnostis,Athanasios I Papadopoulos

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Estrogen Receptor beta antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Receptor beta antibody (AB5786)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise