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AB62257

Anti-Estrogen Receptor beta (phospho S105) antibody

5

(1 Review)

|

(5 Publications)

Rabbit Polyclonal ESR2 phospho S105 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ESR2 pS105 aa 50-150.

View Alternative Names

ESTRB, NR3A2, ESR2, Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Estrogen Receptor beta (phospho S105) antibody (AB62257)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Estrogen Receptor beta (phospho S105) antibody (AB62257)

ab62257 at 1/500 - 1/1000 dilution staining Estrogen Receptor beta in HuvEc cells by Immunofluorescence, in the absence or presence of the immunising peptide

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human ESR2 pS105 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q92731

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab62257 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Receptor beta (ERβ) also known as ERbeta or beta receptor is an important nuclear receptor involved in mediating the effects of estrogens such as estradiol. This receptor with a molecular weight of approximately 59 kDa resides mainly in endothelial and epithelial tissues and can also be present in the central nervous system. ERβ possesses the ability to bind ligands and translocate to the nucleus where it regulates the transcription of specific target genes.
Biological function summary

Estrogen Receptor beta plays a significant role in cell growth regulation and differentiation. It often forms dimers with Estrogen Receptor alpha (ERα) contributing to the diversity of estrogen signaling responses. As part of the nuclear receptor family ERβ engages in binding with DNA at estrogen response elements influencing various physiological processes. The presence of ERβ in tissues implies it has a potentially protective role possibly balancing the actions of ERα.

Pathways

Estrogen Receptor beta plays an essential role in the estrogen signaling pathway and the apoptosis pathway. Interaction with ERα can influence pathways related to cell proliferation and survival contributing to distinct physiological outcomes. ERβ's involvement with proteins like the retinoic acid receptor within these pathways highlights its impact on controlling gene expression important for cell cycle regulation and programmed cell death.

Estrogen Receptor beta has implications in cancers and cardiovascular diseases. In breast cancer ERβ may act differently from ERα possibly providing protective effects against tumor growth. Moreover the receptor's expression affects cardiovascular health by modulating inflammation and vascular function. ERβ interacts with proteins such as p53 hinting at its role in controlling cellular stress responses and combating oncogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed : 20074560).. Isoform 2. Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
See full target information ESR2 pS105
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Aging cell 20:e13336 PubMed33720528

2021

PA28α overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Adelöf,John Wiseman,Madeleine Zetterberg,Malin Hernebring

Toxicology 426:152256 PubMed31381935

2019

Luteolin-7-O-glucoside protects dopaminergic neurons by activating estrogen-receptor-mediated signaling pathway in MPTP-induced mice.

Applications

Unspecified application

Species

Unspecified reactive species

Liyue Qin,Ziyu Chen,Liu Yang,Hailian Shi,Hui Wu,Beibei Zhang,Weiqi Zhang,Qi Xu,Fei Huang,Xiaojun Wu

BMC neuroscience 19:70 PubMed30400847

2018

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Adelöf,My Andersson,Michelle Porritt,Anne Petersen,Madeleine Zetterberg,John Wiseman,Malin Hernebring

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 7:485-95 PubMed22258476

2012

Combining the multitargeted tyrosine kinase inhibitor vandetanib with the antiestrogen fulvestrant enhances its antitumor effect in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jill M Siegfried,Christopher T Gubish,Mary E Rothstein,Cassandra Henry,Laura P Stabile

The American journal of pathology 177:1079-86 PubMed20696772

2010

Phosphorylation of estrogen receptor beta at serine 105 is associated with good prognosis in breast cancer.

Applications

WB, IHC-P

Species

Human, Human

Werbena Hamilton-Burke,Louise Coleman,Michele Cummings,Caroline A Green,Deborah L Holliday,Kieran Horgan,Loaie Maraqa,Mark B Peter,Steven Pollock,Abeer M Shaaban,Laura Smith,Valerie Speirs
View all publications
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Product promise

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