Name: Anti-Estrogen Related Receptor gamma antibody - N-terminal (ab150539) | Abcam
Brand: Abcam Limited
SKU: AB150539

AB150539

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(1 Publication)

Rabbit Polyclonal Estrogen Related Receptor gamma antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ESRRG.

View Alternative Names

ERR3, ERRG2, KIAA0832, NR3B3, ESRRG, Estrogen-related receptor gamma, ERR gamma-2, Estrogen receptor-related protein 3, Nuclear receptor subfamily 3 group B member 3

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Related Receptor gamma antibody - N-terminal (AB150539)

IHC-P

Unknown

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue labelling Estrogen Related Receptor gamma with ab150539 at 5µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ESRRG. The exact immunogen used to generate this antibody is proprietary information.

P62508

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except ESRRB (64%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Lizard": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Opossum": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Platypus": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Turkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Related Receptor gamma (ERRγ) also known as NR3B3 is a nuclear receptor that functions as a transcription factor. This protein regulates gene expression by binding to specific DNA sequences. ERRγ has a mass of approximately 51 kDa. It is expressed in various tissues including the heart skeletal muscle brain kidney and liver. As an orphan receptor ERRγ does not have a known endogenous ligand which impacts how it responds to different cellular signals.

Biological function summary

ERRγ influences several important physiological processes. This receptor is involved in energy metabolism mitochondrial biogenesis and cellular differentiation. ERRγ often operates as part of a larger transcriptional regulatory complex interacting with co-regulators such as PGC-1α to modulate its activity. By binding to specific genes ERRγ modulates processes like glucose metabolism fatty acid oxidation and oxidative phosphorylation which are vital for cellular energy homeostasis.

Pathways

ERRγ plays a significant role in the regulation of energy homeostasis and mitochondrial function. It is an important player in the PGC-1α signaling pathway influencing the expression of genes involved in mitochondrial biogenesis and respiration. ERRγ interacts closely with Peroxisome Proliferator-Activated Receptor (PPAR) pathways enhancing the transcription of genes required for fatty acid metabolism. These interactions contribute to the adaptive response of cells to changes in energy demands and nutrient availability.

ERRγ associates with metabolic conditions and neurodegenerative diseases. Abnormal ERRγ activity has links to metabolic syndrome which includes obesity and diabetes highlighting its role in energy metabolism and insulin sensitivity. Additionally ERRγ expression changes in neurodegenerative disorders like Alzheimer's disease where it interacts with proteins like PGC-1α and influences neuronal survival and function. Understanding these associations might offer new therapeutic targets for managing these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.

See full target information ESRRG

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of the American Heart Association 5: PubMed27742615

2016

Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda J Kennedy,Peiran Yang,Cai Read,Rhoda E Kuc,Lucy Yang,Emily J A Taylor,Colin W Taylor,Janet J Maguire,Anthony P Davenport

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Estrogen Related Receptor gamma antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Related Receptor gamma antibody - N-terminal (AB150539)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise