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AB122245

Anti-ETAA1 antibody

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(3 Publications)

Rabbit Polyclonal ETAA1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETAA1 aa 350-500.

View Alternative Names

ETAA16, ETAA1, Ewing's tumor-associated antigen 1, Ewing's tumor-associated antigen 16

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ETAA1 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.

Q9NY74

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETAA1 also known as Ewing tumor-associated antigen 1 is a protein recognized for its role in DNA replication stress response. It is approximately 92 kDa in mass and ubiquitously expressed in various human tissues. ETAA1 functions at the mechanical level by activating the ATR (ataxia telangiectasia and Rad3-related) kinase an enzyme critical for maintaining genomic stability. This protein contains ATR activators that allow the phosphorylation of various substrates participating in DNA damage repair.
Biological function summary

ETAA1 plays a significant role in the cellular response to replication stress ensuring accurate DNA replication and repair. It does not function as a single entity but acts as part of the ATR activation complex which is involved in sensing and signaling DNA damage. By facilitating ATR activation ETAA1 helps coordinate cell cycle checkpoints and repair processes maintaining genomic integrity under stress conditions.

Pathways

ETAA1 integrates into the DNA damage response pathway and cellular cycle regulation. It operates closely with ATR within the DDR (DNA Damage Response) pathway sharing functional interactions with proteins like TopBP1 and Rad17 which also contribute to ATR activation. Together these proteins ensure the monitoring and repairing of DNA lesions therefore preventing the accumulation of mutations.

ETAA1 associates with cancer and developmental disorders linked to genomic instability. Its dysfunction or altered expression can disrupt the DNA damage response potentially leading to the accumulation of mutations seen in different cancers. The interaction of ETAA1 with ATR emphasizes this relationship as both proteins become pivotal in responding to DNA damage and maintaining cellular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed : 27601467, PubMed : 27723717, PubMed : 27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed : 27723717, PubMed : 27723720, PubMed : 30139873). Probably only regulates a subset of ATR targets (PubMed : 27723717, PubMed : 27723720).
See full target information ETAA1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell metabolism 36:2130-2145.e7 PubMed39084216

2024

Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Tongtong Wang,Anand Kumar Sharma,Chunyan Wu,Claudia Irene Maushart,Adhideb Ghosh,Wu Yang,Patrik Stefanicka,Zuzana Kovanicova,Jozef Ukropec,Jing Zhang,Myrtha Arnold,Manuel Klug,Katrien De Bock,Ulrich Schneider,Cristina Popescu,Bo Zheng,Lianggong Ding,Fen Long,Revati Sumukh Dewal,Caroline Moser,Wenfei Sun,Hua Dong,Martin Takes,Dominique Suelberg,Alexander Mameghani,Antonio Nocito,Christoph Johannes Zech,Alin Chirindel,Damian Wild,Irene A Burger,Michael R Schön,Arne Dietrich,Min Gao,Markus Heine,Yizhi Sun,Ariana Vargas-Castillo,Susanna Søberg,Camilla Scheele,Miroslav Balaz,Matthias Blüher,Matthias Johannes Betz,Bruce M Spiegelman,Christian Wolfrum

Nucleic acids research 50:10503-10525 PubMed36200829

2022

APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Li,Haichao Zhao,Anne McMahon,Shan Yan

The Journal of cell biology 218:2865-2875 PubMed31366665

2019

Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions.

Applications

Unspecified application

Species

Unspecified reactive species

Jone Michelena,Marco Gatti,Federico Teloni,Ralph Imhof,Matthias Altmeyer
View all publications
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Product promise

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