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AB103910

Anti-ETFDH antibody

3

(1 Review)

|

(1 Publication)

Goat Polyclonal ETFDH antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ETFDH aa 500 to C-terminus.

View Alternative Names

ETF-QO, ETF-ubiquinone oxidoreductase, Electron-transferring-flavoprotein dehydrogenase, ETF dehydrogenase, ETFDH

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ETFDH aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q16134

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Alternative Products

Primary Antibodies

AB224663

Anti-ETFDH antibody - C-terminal

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Primary Antibodies

AB131376

Anti-ETFDH antibody [3D1AC4AF3]

BOND RX™ Validated

Flow Cytometry - Anti-ETFDH antibody [3D1AC4AF3] (AB131376)

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Primary Antibodies

AB126576

Anti-ETFDH antibody [3H2BG1]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETFDH antibody [3H2BG1] (AB126576)

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Complementary Products

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AB240593

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Primary Antibodies

AB92461

Anti-ACADM/MCAD antibody [EPR3708]

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Primary Antibodies

AB156571

Anti-ACADS/SCAD antibody [EPR10862(B)]

RabMAb|Recombinant

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Primary Antibodies

AB99951

Anti-SBCAD antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SBCAD antibody (AB99951)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab103910 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETFDH also known as Electron Transfer Flavoprotein Dehydrogenase plays an important role in transferring electrons within the mitochondrial respiratory chain. With a molecular mass of approximately 65 kDa it is predominantly expressed in tissues with high energy demands such as muscle and liver. ETFDH operates as a component of the electron transport chain facilitating electron transfer from the electron transfer flavoprotein (ETF) to the ubiquinone pool.
Biological function summary

The action of ETFDH assists in fatty acid and amino acid metabolism. As part of the larger electron transport chain complex ETFDH partners with both ETF-alpha and ETF-beta subunits to facilitate electron transfer. This process is key in the oxidation of fatty acids particularly in the beta-oxidation pathway. The functional activity of ETFDH helps convert energy stored in macronutrients into adenosine triphosphate (ATP) a necessary energy currency in cells.

Pathways

ETFDH has a critical role in both the beta-oxidation of fatty acids and the catabolism of certain amino acids. Within these pathways it acts as an intersection between the mitochondria and cellular energy production. ETFDH operates with other proteins such as ACAD9 and ACADVL to ensure efficient energy conversion and maintain cellular homeostasis. These pathways highlight ETFDH's involvement in mitochondrial function and overall energy metabolism.

Mutations in the ETFDH gene are linked to conditions like multiple acyl-CoA dehydrogenase deficiency (MADD) and glutaric acidemia type II. These metabolic disorders arise from deficiencies in energy metabolism often leading to severe clinical symptoms. ETFDH's interaction with proteins like ACAD9 can influence the severity and onset of these conditions emphasizing its medical significance in metabolic health. Understanding ETFDH's operation provides insight into potential therapeutic targets for related metabolic diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Accepts electrons from ETF and reduces ubiquinone.
See full target information ETFDH
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of dairy science 103:10728-10741 PubMed32952018

2020

Knockdown of phosphatase and tensin homolog (PTEN) inhibits fatty acid oxidation and reduces very low density lipoprotein assembly and secretion in calf hepatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Bichen Zhao,Chunhai Luo,Menglong Zhang,Feifei Xing,Shengbin Luo,Shixin Fu,Xudong Sun
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Product promise

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