AB150489

Anti-ETL antibody

Name: Anti-ETL antibody (ab150489) | Abcam
Brand: Abcam Limited
SKU: AB150489
Price: 630 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(3 Publications)

Rabbit Polyclonal ETL antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRL4.

View Alternative Names

ELTD1, ETL, UNQ202/PRO228, ADGRL4, Adhesion G protein-coupled receptor L4, EGF-TM7-latrophilin-related protein, ETL protein

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (AB150489)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (AB150489)

Immunohistochemical analysis of paraffin embedded Human heart tissue labelling ETL with ab150489 antibody at a concentration of 11 µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ADGRL4. The exact immunogen used to generate this antibody is proprietary information.

Q9HBW9

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "4-11 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Turkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETL sometimes referred to as ETL 500 or ETL Ziegler plays a mechanical role in cellular processes. This target has a molecular mass of approximately 50 kDa. ETL is widely expressed in various tissues and can be detected in both normal and pathogenic states showing particular abundance in organ-specific cells. It exists as a singular protein or engages in complex formations depending on its function and cellular location.

Biological function summary

ETL contributes significantly to the regulation of cellular transport mechanisms. It often functions as part of larger protein complexes associating with cellular structures involved in the trafficking of molecules within the cell. ETL’s interaction with these complexes facilitates intracellular movement and integrity influencing cellular responses to external signals.

Pathways

ETL holds a significant position within the intracellular signaling pathway and the protein transport pathway. Important protein interactions include those with transport-related pathways like the molecules involved in endocytosis and exocytosis. ETL's pathway involvement indicates its functional relevance in cellular maintenance and communication linking it to key structural proteins.

ETL shows association with neurodegenerative diseases and some types of cancer. In neurodegenerative conditions ETL interacts with proteins involved in neural cell communication indicating a role in disease progression. Within cancer-related processes ETL partners with oncogenic proteins hinting at its potential as a target for therapeutic intervention in malignancies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Endothelial orphan receptor that acts as a key regulator of angiogenesis.

See full target information ADGRL4

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Multiple sclerosis and related disorders 49:102786 PubMed33517175

2021

ELTD1 as a biomarker for multiple sclerosis: Pre-clinical molecular-targeted studies in a mouse experimental autoimmune encephalomyelitis model.

Applications

Unspecified application

Species

Unspecified reactive species

Rheal A Towner,Nataliya Smith,Michelle Zalles,Sara Morris,MacKenzie Toliver,Debra Saunders,Megan Lerner,Gaurav Kumar,Robert C Axtell

American journal of nuclear medicine and molecular 9:93-109 PubMed30911439

2019

Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment.

Applications

Unspecified application

Species

Unspecified reactive species

Jadith Ziegler,Michelle Zalles,Nataliya Smith,Debra Saunders,Megan Lerner,Kar-Ming Fung,Maulin Patel,Jonathan D Wren,Florea Lupu,James Battiste,Rheal A Towner

Neuro-oncology 19:175-185 PubMed27416955

2016

ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.

Applications

Unspecified application

Species

Unspecified reactive species

Jadith Ziegler,Richard Pody,Patricia Coutinho de Souza,Blake Evans,Debra Saunders,Nataliya Smith,Samantha Mallory,Charity Njoku,Yunzhou Dong,Hong Chen,Jiali Dong,Megan Lerner,Osamah Mian,Sai Tummala,James Battiste,Kar-Ming Fung,Jonathan D Wren,Rheal A Towner

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ETL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (AB150489)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise