Rabbit Polyclonal ETL antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRL4.
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Publications
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- Multiple sclerosis and related disorders 49:1027862021ELTD1 as a biomarker for multiple sclerosis: Pre-clinical molecular-targeted studies in a mouse experimental autoimmune encephalomyelitis model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRheal A Towner,Nataliya Smith,Michelle Zalles,Sara Morris,MacKenzie Toliver,Debra Saunders,Megan Lerner,Gaurav Kumar,Robert C AxtellPubMed 33517175
- American journal of nuclear medicine and molecular 9:93-1092019Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJadith Ziegler et. al.PubMed 30911439
- Neuro-oncology 19:175-1852016ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJadith Ziegler,Richard Pody,Patricia Coutinho de Souza,Blake Evans,Debra Saunders,Nataliya Smith,Samantha Mallory,Charity Njoku,Yunzhou Dong,Hong Chen,Jiali Dong,Megan Lerner,Osamah Mian,Sai Tummala,James Battiste,Kar-Ming Fung,Jonathan D Wren,Rheal A TownerPubMed 27416955
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ADGRL4. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HBW9
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Bat | Predicted |
| Chicken | Predicted |
| Cow | Predicted |
| Dog | Predicted |
| Gorilla | Predicted |
| Horse | Predicted |
| Monkey | Predicted |
| Pig | Predicted |
| Rabbit | Predicted |
| Turkey | Predicted |
| Xenopus laevis | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 4.00000-11.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Rabbit, Horse, Cow, Dog, Turkey, Pig, Xenopus laevis, Monkey, Bat, Gorilla, Chicken | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Endothelial orphan receptor that acts as a key regulator of angiogenesis.
Alternative names
ELTD1, ETL, UNQ202/PRO228, ADGRL4, Adhesion G protein-coupled receptor L4, EGF-TM7-latrophilin-related protein, ETL protein
Recommended products
Rabbit Polyclonal ETL antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRL4.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ADGRL4. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HBW9
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ETL sometimes referred to as ETL 500 or ETL Ziegler plays a mechanical role in cellular processes. This target has a molecular mass of approximately 50 kDa. ETL is widely expressed in various tissues and can be detected in both normal and pathogenic states showing particular abundance in organ-specific cells. It exists as a singular protein or engages in complex formations depending on its function and cellular location.
- Biological function summary
ETL contributes significantly to the regulation of cellular transport mechanisms. It often functions as part of larger protein complexes associating with cellular structures involved in the trafficking of molecules within the cell. ETL’s interaction with these complexes facilitates intracellular movement and integrity influencing cellular responses to external signals.
- Pathways
ETL holds a significant position within the intracellular signaling pathway and the protein transport pathway. Important protein interactions include those with transport-related pathways like the molecules involved in endocytosis and exocytosis. ETL's pathway involvement indicates its functional relevance in cellular maintenance and communication linking it to key structural proteins.
- Associated diseases and disorders
ETL shows association with neurodegenerative diseases and some types of cancer. In neurodegenerative conditions ETL interacts with proteins involved in neural cell communication indicating a role in disease progression. Within cancer-related processes ETL partners with oncogenic proteins hinting at its potential as a target for therapeutic intervention in malignancies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (ab150489)
Immunohistochemical analysis of paraffin embedded Human heart tissue labelling ETL with ab150489 antibody at a concentration of 11 µg/ml.
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