AB217175

Anti-ETL antibody

Name: Anti-ETL antibody (ab217175) | Abcam
Brand: Abcam Limited
SKU: AB217175
Price: 520 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal ETL antibody. Suitable for IHC-P, Flow Cyt and reacts with Rat, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRL4 aa 300-400 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

ELTD1, ETL, UNQ202/PRO228, ADGRL4, Adhesion G protein-coupled receptor L4, EGF-TM7-latrophilin-related protein, ETL protein

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (AB217175)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (AB217175)

Immunohistochemical analysis of formalin-fixed paraffin-embedded rat uterus tissue, labeling ETL using ab217175 at a 1/500 dilution, followed by a secondary goat anti-rabbit IgG antibody conjugated to Cy3 at a 1/200 dilution and DAPI staining.

Flow Cytometry - Anti-ETL antibody (AB217175)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-ETL antibody (AB217175)

Flow cytometry analysis of mouse kidney lysates labeling ETL (green), using ab217175 at a 1/100 dilution, and unstained cells cells (blue). FITC-conjugated secondary antibodies were used for the analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (AB217175)

Immunohistochemical analysis of formalin-fixed paraffin-embedded rat uterus tissue, labeling ETL using ab217175 at a 1/500 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat

Applications

Flow Cyt, IHC-P

applications

Immunogen

Synthetic Peptide within Human ADGRL4 aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9HBW9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/100", "FlowCyt-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>When using a fluorescent probe the recommended dilution is 1/50 – 1/500.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETL sometimes referred to as ETL 500 or ETL Ziegler plays a mechanical role in cellular processes. This target has a molecular mass of approximately 50 kDa. ETL is widely expressed in various tissues and can be detected in both normal and pathogenic states showing particular abundance in organ-specific cells. It exists as a singular protein or engages in complex formations depending on its function and cellular location.

Biological function summary

ETL contributes significantly to the regulation of cellular transport mechanisms. It often functions as part of larger protein complexes associating with cellular structures involved in the trafficking of molecules within the cell. ETL’s interaction with these complexes facilitates intracellular movement and integrity influencing cellular responses to external signals.

Pathways

ETL holds a significant position within the intracellular signaling pathway and the protein transport pathway. Important protein interactions include those with transport-related pathways like the molecules involved in endocytosis and exocytosis. ETL's pathway involvement indicates its functional relevance in cellular maintenance and communication linking it to key structural proteins.

ETL shows association with neurodegenerative diseases and some types of cancer. In neurodegenerative conditions ETL interacts with proteins involved in neural cell communication indicating a role in disease progression. Within cancer-related processes ETL partners with oncogenic proteins hinting at its potential as a target for therapeutic intervention in malignancies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Endothelial orphan receptor that acts as a key regulator of angiogenesis.

See full target information ADGRL4

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancers 15: PubMed36765785

2023

Flexible Cyclic Immunofluorescence (cyCIF) Using Oligonucleotide Barcoded Antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Nathan P McMahon,Jocelyn A Jones,Ashley N Anderson,Matthew S Dietz,Melissa H Wong,Summer L Gibbs

Clinical and experimental pharmacology & physiology 49:686-695 PubMed35320597

2022

STAT5A modulated EndMT via upregulation of ELTD1 expression in diabetic nephropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Ye Tian,Zhenhua Bi,Shuaina Ge,Bo Ye,Wenjie Han

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ETL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (AB217175)

Flow Cytometry - Anti-ETL antibody (AB217175)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody (AB217175)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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