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AB219974

Anti-ETL antibody [CL4164]

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(2 Publications)

Mouse Monoclonal ETL antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADGRL4 aa 50-200.

View Alternative Names

ELTD1, ETL, UNQ202/PRO228, ADGRL4, Adhesion G protein-coupled receptor L4, EGF-TM7-latrophilin-related protein, ETL protein

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)

Immunohistochemical analysis of paraffin-embedded human cerebellum tissue labeling ETL with ab219974 at 1/500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)

Immunohistochemical analysis of paraffin-embedded human placenta tissue labeling ETL with ab219974 at 1/500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)

Immunohistochemical analysis of paraffin-embedded human fallopian tube tissue labeling ETL with ab219974 at 1/500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)

Immunohistochemical analysis of paraffin-embedded human liver tissue labeling ETL with ab219974 at 1/500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETL antibody [CL4164] (AB219974)

Immunohistochemical analysis of paraffin-embedded human stomach tissue labeling ETL with ab219974 at 1/500 dilution.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CL4164

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human ADGRL4 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q9HBW9

Epitope

Binds to an epitope located within the peptide sequence CVPGFRSSSN (aa 86-95) as determined by overlapping synthetic peptides.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETL sometimes referred to as ETL 500 or ETL Ziegler plays a mechanical role in cellular processes. This target has a molecular mass of approximately 50 kDa. ETL is widely expressed in various tissues and can be detected in both normal and pathogenic states showing particular abundance in organ-specific cells. It exists as a singular protein or engages in complex formations depending on its function and cellular location.
Biological function summary

ETL contributes significantly to the regulation of cellular transport mechanisms. It often functions as part of larger protein complexes associating with cellular structures involved in the trafficking of molecules within the cell. ETL’s interaction with these complexes facilitates intracellular movement and integrity influencing cellular responses to external signals.

Pathways

ETL holds a significant position within the intracellular signaling pathway and the protein transport pathway. Important protein interactions include those with transport-related pathways like the molecules involved in endocytosis and exocytosis. ETL's pathway involvement indicates its functional relevance in cellular maintenance and communication linking it to key structural proteins.

ETL shows association with neurodegenerative diseases and some types of cancer. In neurodegenerative conditions ETL interacts with proteins involved in neural cell communication indicating a role in disease progression. Within cancer-related processes ETL partners with oncogenic proteins hinting at its potential as a target for therapeutic intervention in malignancies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Endothelial orphan receptor that acts as a key regulator of angiogenesis.
See full target information ADGRL4
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

EXCLI journal 23:888-903 PubMed38983778

2024

Unveiling the Ro60-Ro52 complex.

Applications

Unspecified application

Species

Unspecified reactive species

Laura R Rodríguez,Jesus Vicente de Julián-Ortiz,Fernando Rubio de la Rúa,Augusto Juste-Dolz,Ángel Maquieira,Haydar A Mohammad-Salim,Sofiane Benmetir,Federico V Pallardó,Pilar González-Cabo,David Gimenez-Romero

Medical molecular morphology 57:200-217 PubMed38960952

2024

Histopathological growth pattern and vessel co-option in intrahepatic cholangiocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zihan Li,Hiep Nguyen Canh,Kenta Takahashi,Dong Le Thanh,Quynh Nguyen Thi,Rui Yang,Kaori Yoshimura,Yasunori Sato,Khuyen Nguyen Thi,Hiroki Nakata,Hiroko Ikeda,Kazuto Kozaka,Satoshi Kobayashi,Shintaro Yagi,Kenichi Harada
View all publications
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Product promise

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