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AB186844

Anti-ETS1 antibody

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(8 Publications)

Rabbit Polyclonal ETS1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Rat samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETS1.

View Alternative Names

EWSR2, ETS1, Protein C-ets-1, p54

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS1 antibody (AB186844)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS1 antibody (AB186844)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach cancer tissue labelling ETS1 with ab186844 at 1/200. Magnification : 400x.

Immunocytochemistry/ Immunofluorescence - Anti-ETS1 antibody (AB186844)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ETS1 antibody (AB186844)

Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186844. Blue DAPI for nuclear staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS1 antibody (AB186844)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS1 antibody (AB186844)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling ETS1 with ab186844 at 1/200. Magnification : 400x.

Western blot - Anti-ETS1 antibody (AB186844)
  • WB

Supplier Data

Western blot - Anti-ETS1 antibody (AB186844)

All lanes:

Western blot - Anti-ETS1 antibody (ab186844) at 1/500 dilution

Lane 1:

U937 cell extract

Lane 2:

Raji cell extract

Lane 3:

Jurkat cell extract

Lane 4:

ES2 cell extract

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ETS1. The exact immunogen used to generate this antibody is proprietary information.

P14921

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETS1 also known as E26 Transformation-Specific 1 is a transcription factor protein weighing approximately 51-53 kDa. It belongs to the ETS family of transcription factors and can be referred to by other names such as ETS-1 ETS 1 or Ets-1. This protein shows expression in numerous tissues including the thymus spleen and brain. Importantly ETS1 binds to specific DNA sequences to regulate the transcription of various target genes.
Biological function summary

The function of this protein involves the regulation of gene expression linked to cell development differentiation and apoptosis. ETS1 does not form stable complexes with other proteins in its resting form but it can interact dynamically with co-factors during activation. Its activity plays a role in immune response modulation and vascular development by controlling downstream target genes connected to these processes.

Pathways

The involvement of this protein spans key signal transduction pathways including the MAPK and PI3K/AKT pathways. In these pathways ETS1 regulates gene expression influenced by external stimuli such as growth factors. It interacts with other pathway-related proteins like ERK1/2 and AKT initiating cellular responses that contribute to cell proliferation and survival mechanisms.

Abnormalities in the function or expression of this protein have been linked to certain cancers such as leukemia and breast cancer. The protein interacts with other oncogenic proteins including BRISA and Palikuqi leading to progression of these malignancies. Additionally involvement in autoimmune disorders like lupus has been observed where deregulation of ETS1 can affect immune cell behavior and promote hyperactivation of immune responses.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Transcription factor (PubMed : 10698492, PubMed : 11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed : 20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed : 20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed : 15247905, PubMed : 15592518).. Isoform Ets-1 p27. Acts as a dominant-negative for isoform c-ETS-1A.
See full target information ETS1

Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational internal medicine 13:267-280 PubMed40896288

2025

CircPLK1 upregulates ETS1 to confer anthracycline resistance in triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Danian Dai,Jinhui Zhang,Yunxian Mo,Cailu Song,Lingrui Liu,Zhe-Sheng Chen,Hailin Tang,Bo Chen

Oncology letters 28:453 PubMed39100995

2024

Transcription factor ETS1‑mediated ECT2 expression promotes the malignant behavior of prostate cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Zheng,Kuifu Chen,Xin Liu,Zhenghua Wan,Yulong Wu,Liming Xu,Jiguang Xiao,Jinqu Chen

Journal of biochemical and molecular toxicology 36:e23070 PubMed35403324

2022

Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Wu,Xi'an Zhang,Shijun Li,Lina Wang,Jie Bai,Hanxiang Wang,Qing Shu

Frontiers in cell and developmental biology 9:708562 PubMed34900980

2021

HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1.

Applications

Unspecified application

Species

Unspecified reactive species

Jianqin Li,Yalin Xia,Xiaoru Fan,Xiaofang Wu,Feiyun Yang,Shaoyan Hu,Zhaoyue Wang

Journal of cellular and molecular medicine 25:8148-8158 PubMed34378314

2021

Overexpression of lncRNA SLC26A4-AS1 inhibits papillary thyroid carcinoma progression through recruiting ETS1 to promote ITPR1-mediated autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Peng,Wenfa Li,Bojuan Zhang,Xuefen Liu

OncoTargets and therapy 13:11957-11973 PubMed33239895

2020

Histone Demethylase Promotes Cervical Cancer Malignancy Through the /KIF14/Hedgehog Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jinyu Liu,Dongqing Li,Xin Zhang,Yanyan Li,Jian Ou

Cancer biology & therapy 20:461-473 PubMed30404587

2018

Knockdown of linc00152 inhibits the progression of gastric cancer by regulating microRNA-193b-3p/ETS1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Haifang Wang,Wenxiang Chen,Peng Yang,Jun Zhou,Kaiyuan Wang,Qingchun Tao

BioMed research international 2018:3536854 PubMed30046593

2018

C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

K Dergilev,Z Tsokolaeva,P Makarevich,I Beloglazova,E Zubkova,M Boldyreva,E Ratner,D Dyikanov,M Menshikov,A Ovchinnikov,F Ageev,Ye Parfyonova
View all publications

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