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AB140371

Anti-ETS2 antibody [OTI1H4]

4

(1 Review)

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(1 Publication)

Mouse Monoclonal ETS2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Protein C-ets-2 aa 50-350.

View Alternative Names

Protein C-ets-2, ETS2

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS2 antibody [OTI1H4] (AB140371)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS2 antibody [OTI1H4] (AB140371)

Immunohistochemical analysis of paraffin-embedded Human endometrium adenocarcinoma tissue labelling ETS2 with ab140371 at 1/150 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS2 antibody [OTI1H4] (AB140371)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS2 antibody [OTI1H4] (AB140371)

Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labelling ETS2 with ab140371 at 1/150 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS2 antibody [OTI1H4] (AB140371)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS2 antibody [OTI1H4] (AB140371)

Immunohistochemical analysis of paraffin-embedded Human pancreas tissue labelling ETS2 with ab140371 at 1/150 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS2 antibody [OTI1H4] (AB140371)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETS2 antibody [OTI1H4] (AB140371)

Immunohistochemical analysis of paraffin-embedded Human thyroid carcinoma tissue labelling ETS2 with ab140371 at 1/150 dilution.

Western blot - Anti-ETS2 antibody [OTI1H4] (AB140371)
  • WB

Unknown

Western blot - Anti-ETS2 antibody [OTI1H4] (AB140371)

HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC208418)

All lanes:

Western blot - Anti-ETS2 antibody [OTI1H4] (ab140371) at 1/4000 dilution

Lane 1:

HEK293T cells transfected with pCMV6-ENTRY control cDNA at 5 µg

Lane 2:

HEK293T cells transfected with pCMV6-ENTRY ETS2 cDNA at 5 µg

Predicted band size: 53 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI1H4

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Protein C-ets-2 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.

P15036

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/4000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p></p>" } } }
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Product details

The clone number has been updated from 1H4 to OTI1H4, both clone numbers name the same clone.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
ab140371 is purified fromTCS by affinity chromatography.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETS2 protein or E26 transformation-specific sequence 2 is a transcription factor that is part of the ETS family. This protein is about 56 kDa in mass. It regulates gene expression by binding to specific DNA sequences. ETS2 is widely expressed in various tissues including the heart brain and liver. It influences multiple cellular processes like development proliferation and apoptosis.
Biological function summary

ETS2 protein functions in the regulation of genes that control critical cellular activities. The protein can form complexes with other transcription factors to modulate gene expression. It can interact with other proteins to influence cellular responses to external signals. As a transcription factor ETS2 also has a role in cellular differentiation and morphogenesis contributing to the development of multicellular organisms.

Pathways

ETS2 protein is involved in key signaling pathways such as the MAPK/ERK pathway and PI3K/AKT pathway. These pathways play essential roles in cell cycle regulation apoptosis and cell growth. ETS2 interacts with proteins like MAPK and AKT to transmit signals from the cell membrane to the nucleus. These interactions help coordinate responses to growth factors and stress signals influencing cellular outcomes.

The ETS2 protein has been linked to cancer and Down syndrome. In cancer dysregulation of ETS2 can lead to abnormal cell proliferation and resistance to apoptosis contributing to tumor development. In Down syndrome an extra copy of the ETS2 gene on chromosome 21 may affect normal development and contribute to associated phenotypes. ETS2's interaction with proteins like MYC and RAS can exacerbate these conditions influencing disease progression and outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
See full target information Protein C-ets-2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:19589 PubMed37949903

2023

IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Tara E Scott,Caitlin V Lewis,Mingyu Zhu,Chao Wang,Chrishan S Samuel,Grant R Drummond,Barbara K Kemp-Harper
View all publications
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