Anti-ETV3 antibody [EPR8658]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ETV3 also known as ETS Variant 3 functions as a transcriptional repressor. The protein has a mass of approximately 61 kDa. It is expressed in multiple tissues including skin liver and immune cells. The presence of ETV3 is important for regulating gene expression as it can bind to specific DNA sequences and inhibit transcription of target genes. This ability allows ETV3 to maintain control over cellular processes such as proliferation and differentiation.

Biological function summary

The functionality of ETV3 extends to modulation of immune responses and cellular development. ETV3 along with other transcription factors forms parts of multi-protein complexes. Its role in these complexes involves the repression of gene activity directly influencing cell cycle progression and immune system activity. ETV3’s expression and interactions suggest it coordinates with other molecules to maintain homeostasis and appropriate cellular functions.

Pathways

ETV3 integrates into two main biological pathways: the MAPK signaling pathway and immune response regulation. Within the MAPK pathway ETV3 interacts with proteins such as ERK influencing cell survival and differentiation outcomes. Meanwhile it connects in immune pathways by modulating activity of other transcription factors impacting immune cell behaviors and responses.

Associated diseases and disorders

ETV3 plays a role in conditions like skin cancer and immune system diseases. Aberrant expression or mutation of ETV3 correlates with melanoma development where disrupted regulation contributes to abnormal cell proliferation. Its interactions with proteins such as MITF are particularly relevant in melanoma. Additionally ETV3's role in immune modulation can influence autoimmune disorders where dysregulation leads to improper immune activation or repression.