AB185816

Anti-ETV6 / Tel antibody

Name: Anti-ETV6 / Tel antibody (ab185816) | Abcam
Brand: Abcam Limited
SKU: AB185816

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(1 Publication)

Rabbit Polyclonal ETV6 / Tel antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ETV6 aa 1-300.

View Alternative Names

TEL, TEL1, ETV6, Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB185816)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB185816)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling ETV6 / Tel with ab185816 at 1/200. Magnification : 400x.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB185816)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung cancer tissue labelling ETV6 / Tel with ab185816 at 1/200. Magnification : 400x.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB185816)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human esophagus tissue labelling ETV6 / Tel with ab185816 at 1/200. Magnification : 400x.

Supplier Data

Western blot - Anti-ETV6 / Tel antibody (AB185816)

All lanes:

Western blot - Anti-ETV6 / Tel antibody (ab185816) at 1/500 dilution

All lanes:

A431 cell line extracts

Predicted band size: 53 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ETV6 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

P41212

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-polyclonal-isotype-control-chip-grade-ab171870'>ab171870</a> - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETV6 also known as Tel is a transcription factor encoded by the ETV6 gene. It weighs approximately 57 kDa. The protein is expressed in various tissues including hematopoietic cells which are cells that form blood cells. ETV6 contains a pointed (PNT) domain and an ETS DNA-binding domain which allow it to regulate gene expression by binding to specific DNA sequences. It functions in the nucleus where it influences cell cycle progression and differentiation.

Biological function summary

ETV6 impacts processes key to hematopoiesis and is often part of transcriptional regulatory complexes. It guides critical decisions in hematopoietic stem cells promoting lineage commitment and modulating cell cycle regulation. This protein acts as a repressor or activator depending on the context influencing target gene expression and sustaining the balance necessary for blood cell differentiation and maintenance. Its ability to interact with co-factors like HDACs (histone deacetylases) broadens its regulatory potential.

Pathways

ETV6 integrates into signaling pathways that manage cellular development and proliferation. ETV6 participates in the Ras-MAPK pathway which influences cell growth by regulating transcription of genes essential for these processes. It also interacts closely with proteins like ABL1 in this pathway modulating both kinase activity and gene control highlighting the critical connections it maintains in cell signaling networks.

ETV6 exhibits pivotal roles in oncogenic processes such as those observed in leukemia. Its involvement in translocation events like the ETV6-RUNX1 fusion contributes to the pathogenesis of acute lymphoblastic leukemia (ALL) by altering normal gene regulation. Additionally mutations within ETV6 link it to myelodysplastic syndromes with associated proteins in these disorders including FLT3. This connection highlights the pathogenic impact ETV6 permutations can have within hematological malignancies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.

See full target information ETV6

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature 621:415-422 PubMed37674080

2023

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.

Applications

Unspecified application

Species

Unspecified reactive species

Camille Gelot,Marton Tibor Kovacs,Simona Miron,Emilie Mylne,Alexis Haan,Liza Boeffard-Dosierre,Rania Ghouil,Tatiana Popova,Florent Dingli,Damarys Loew,Josée Guirouilh-Barbat,Elaine Del Nery,Sophie Zinn-Justin,Raphael Ceccaldi

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ETV6 / Tel antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB185816)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB185816)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB185816)

Western blot - Anti-ETV6 / Tel antibody (AB185816)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise