Rabbit Polyclonal ETV6 / Tel antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ETV6 aa 50-250.
View Alternative Names
TEL, TEL1, ETV6, Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)
Immunohistochemical analysis of human skin tissue labeling ETV6 / Tel with ab223705 at 1/200 dilution.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)
Immunohistochemical analysis of human kidney tissue labeling ETV6 / Tel with ab223705 at 1/200 dilution. No staining is observed.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-ETV6 / Tel antibody (AB223705)
PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for ETV6 / Tel (green) using ab223705 at 4 μg/ml in ICC/IF.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)
Immunohistochemical analysis of human breast tissue labeling ETV6 / Tel with ab223705 at 1/200 dilution.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)
Immunohistochemical analysis of human liver tissue labeling ETV6 / Tel with ab223705 at 1/200 dilution. No staining is observed.
Reactivity data
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Supplementary information
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Biological function summary
ETV6 impacts processes key to hematopoiesis and is often part of transcriptional regulatory complexes. It guides critical decisions in hematopoietic stem cells promoting lineage commitment and modulating cell cycle regulation. This protein acts as a repressor or activator depending on the context influencing target gene expression and sustaining the balance necessary for blood cell differentiation and maintenance. Its ability to interact with co-factors like HDACs (histone deacetylases) broadens its regulatory potential.
Pathways
ETV6 integrates into signaling pathways that manage cellular development and proliferation. ETV6 participates in the Ras-MAPK pathway which influences cell growth by regulating transcription of genes essential for these processes. It also interacts closely with proteins like ABL1 in this pathway modulating both kinase activity and gene control highlighting the critical connections it maintains in cell signaling networks.
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Target data
Publications (1)
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The Journal of clinical investigation 133: PubMed36928117
2023
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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