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AB64909

Anti-ETV6 / Tel antibody

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(1 Publication)

Rabbit Polyclonal ETV6 / Tel antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ETV6.
2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ETV6 / Tel antibody (AB64909)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ETV6 / Tel antibody (AB64909)

ab64909, at 1/500 dilution, staining HeLa cells by immunofluorescence in the absence (left) or presence (right) of immunsing peptide.

Western blot - Anti-ETV6 / Tel antibody (AB64909)
  • WB

Unknown

Western blot - Anti-ETV6 / Tel antibody (AB64909)

All lanes:

Western blot - Anti-ETV6 / Tel antibody (ab64909) at 1/500 dilution

Lane 1:

extracts from HeLa cells at 30 µg

Lane 2:

extracts from HepG2 cells at 30 µg

Lane 3:

extracts from Jurkat cells at 30 µg

Lane 4:

extracts from Jurkat cells at 30 µg with immunising peptide

Predicted band size: 53 kDa

Observed band size: 53 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human ETV6. The exact immunogen used to generate this antibody is proprietary information.

P41212

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ETV6 also known as Tel is a transcription factor encoded by the ETV6 gene. It weighs approximately 57 kDa. The protein is expressed in various tissues including hematopoietic cells which are cells that form blood cells. ETV6 contains a pointed (PNT) domain and an ETS DNA-binding domain which allow it to regulate gene expression by binding to specific DNA sequences. It functions in the nucleus where it influences cell cycle progression and differentiation.
Biological function summary

ETV6 impacts processes key to hematopoiesis and is often part of transcriptional regulatory complexes. It guides critical decisions in hematopoietic stem cells promoting lineage commitment and modulating cell cycle regulation. This protein acts as a repressor or activator depending on the context influencing target gene expression and sustaining the balance necessary for blood cell differentiation and maintenance. Its ability to interact with co-factors like HDACs (histone deacetylases) broadens its regulatory potential.

Pathways

ETV6 integrates into signaling pathways that manage cellular development and proliferation. ETV6 participates in the Ras-MAPK pathway which influences cell growth by regulating transcription of genes essential for these processes. It also interacts closely with proteins like ABL1 in this pathway modulating both kinase activity and gene control highlighting the critical connections it maintains in cell signaling networks.

ETV6 exhibits pivotal roles in oncogenic processes such as those observed in leukemia. Its involvement in translocation events like the ETV6-RUNX1 fusion contributes to the pathogenesis of acute lymphoblastic leukemia (ALL) by altering normal gene regulation. Additionally mutations within ETV6 link it to myelodysplastic syndromes with associated proteins in these disorders including FLT3. This connection highlights the pathogenic impact ETV6 permutations can have within hematological malignancies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
See full target information ETV6

Alternative Names

TEL, TEL1, ETV6, Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Nucleic acids research 44:10644-10661 PubMed27604872

2016

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.

Applications

Unspecified application

Species

Unspecified reactive species

Ashwin Unnikrishnan,Yi F Guan,Yizhou Huang,Dominik Beck,Julie A I Thoms,Sofie Peirs,Kathy Knezevic,Shiyong Ma,Inge V de Walle,Ineke de Jong,Zara Ali,Ling Zhong,Mark J Raftery,Tom Taghon,Jonas Larsson,Karen L MacKenzie,Pieter Van Vlierberghe,Jason W H Wong,John E Pimanda
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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