AB229832

Anti-ETV7 antibody

Name: Anti-ETV7 antibody (ab229832) | Abcam
Brand: Abcam Limited
SKU: AB229832
Price: 525 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal ETV7 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETV7 aa 100-250.

View Alternative Names

TEL2, TELB, TREF, ETV7, Transcription factor ETV7, ETS translocation variant 7, ETS-related protein Tel2, Tel-related Ets factor, Transcription factor Tel-2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV7 antibody (AB229832)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV7 antibody (AB229832)

Paraffin-embedded human cervical cancer tissue stained for ETV7 using ab229832 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-ETV7 antibody (AB229832)

All lanes:

Western blot - Anti-ETV7 antibody (ab229832) at 1/500 dilution

All lanes:

Rat liver lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 39 kDa

Observed band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ETV7 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q9Y603

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%.

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ETV7 also known as TEL2 is a member of the ETS family of transcription factors with a molecular weight of approximately 53 kDa. This protein localizes predominantly in the nucleus and influences gene expression regulation. ETV7 is expressed in a variety of tissues with notable expression levels in hematopoietic cells. Its role extends to modulating different genes critical for cellular proliferation and differentiation.

Biological function summary

ETV7 acts as a transcriptional repressor and influences immune responses and cell cycle regulation. This protein functions as part of larger transcriptional complexes interacting with other cofactors to modulate gene expression. ETV7 influences hematopoiesis impacting both the development and function of blood cells by repressing certain cytokine receptors and transcription factors tightly controlling the cellular environment.

Pathways

ETV7 plays an integral role in pathways related to hematopoiesis and immune cell regulation. It participates in the JAK-STAT signaling pathway collaborating with proteins such as STAT5 to regulate immune responses and cell proliferation. Additionally ETV7 is involved in the regulation of cytokine signaling pathways impacting cellular growth and immune system balance.

ETV7 holds significance in the development of certain cancers particularly hematological malignancies. It has associations with acute myeloid leukemia (AML) where its overexpression contributes to leukemogenesis alongside proteins like FLT3. ETV7 also plays a role in B-cell chronic lymphocytic leukemia (CLL) affecting the balance of pro-survival and apoptotic mechanisms further linking its activity with the tumor suppressor protein TP53. Understanding ETV7's interactions helps to illuminate its potential as a therapeutic target in these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity.

See full target information ETV7

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

World journal of oncology 16:409-421 PubMed40810079

2025

Upregulated E26 Transformation-Specific Variant Transcription Factor 7 in Oral Squamous Cell Carcinoma: Clinicopathological Correlations and Immune Regulatory Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Zhi Yong,Jian Di Li,Yu Xing Tang,Rong Quan He,Ping Li,Ren Chuan Tao,Gang Chen

Journal of translational medicine 22:112 PubMed38282047

2024

Exosomal miR-361-3p promotes the viability of breast cancer cells by targeting ETV7 and BATF2 to upregulate the PAI-1/ERK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Li,Lei Fan,An Yan,Xiaotian Ren,Yanyang Zhao,Bin Hua

American journal of nephrology 53:10-20 PubMed34965524

2021

Development of Urinary Diagnostic Biomarker for IgA Nephropathy by Lectin Microarray.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuhiro Onishi,Koki Mise,Chieko Kawakita,Haruhito A Uchida,Hitoshi Sugiyama,Ryosuke Sugawara,Satoshi Yamaguchi,Michihiro Yoshida,Toshiharu Mitsuhashi,Masao Yamada,Jun Hirabayashi,Jun Wada

Frontiers in genetics 12:680413 PubMed34054929

2021

Identification of a Prognostic Signature for Ovarian Cancer Based on the Microenvironment Genes.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Huo,Hengzi Sun,Shuangwu Liu,Bing Liang,Huimin Bai,Shuzhen Wang,Shuhong Li

World journal of gastroenterology 25:5973-5990 PubMed31660034

2019

Differentially expressed long noncoding RNAs and regulatory mechanism of LINC02407 in human gastric adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Li Zhou,Yan Jiao,Hong-Mei Chen,Li-Hua Kang,Qi Yang,Jing Li,Meng Guan,Ge Zhu,Fei-Qi Liu,Shuang Wang,Xue Bai,Yan-Qiu Song

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ETV7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV7 antibody (AB229832)

Western blot - Anti-ETV7 antibody (AB229832)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Complementary Products

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Secondary Antibodies

Primary Antibodies

Primary Antibodies

Product promise