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AB220665

Anti-Evx1 antibody

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(3 Publications)

Rabbit Polyclonal EVX1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EVX1 aa 1-100.

View Alternative Names

Homeobox even-skipped homolog protein 1, EVX-1, EVX1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Evx1 antibody (AB220665)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Evx1 antibody (AB220665)

Immunofluorescent analysis of RT4 cells (PFA-fixed/Triton X-100 permeabilized) labeling Evx1 with ab220665 at 4μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human EVX1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P49640

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Evx1 also known as Even-Skipped Homeobox 1 acts as a transcription factor involved in multiple developmental processes. It belongs to the homeobox gene family and is characterized by a 43 kilodalton mass. Researchers have found Evx1 highly expressed in the embryonic tissue of vertebrates notably in motor neurons and dorsal neural tube regions during early stages of development. Its expression regulates patterns necessary for embryonic morphogenesis and differentiation.
Biological function summary

Evx1 plays a significant role in the regulation of genes essential for embryonic development particularly those involved in neural differentiation and segmentation. This protein interacts with other proteins and forms complexes that modulate gene expression needed for spinal cord development. By influencing the expression of important target genes Evx1 mediates processes important for proper neuronal identity and migration.

Pathways

Evx1 influences several key developmental pathways including the Wnt signaling and Notch signaling pathways. In the Wnt signaling pathway Evx1 interacts with the Wnt proteins to regulate gene transcription and ensure proper pattern formation. Similarly in the Notch signaling pathway Evx1 works alongside Notch proteins contributing to the cell fate decisions and segmental organization. These interactions highlight Evx1's integral role in the precise coordination of embryonic development.

Evx1 has associations with certain developmental abnormalities notably caudal dysgenesis and spina bifida. Such conditions often result from disruptions in normal Evx1 function affecting proper spinal cord formation. The target gene's association with the Wnt and Notch pathways along with proteins like β-catenin and Notch1 links it to these disorders highlighting its importance in maintaining developmental integrity and preventing pathological outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in the specification of neuronal cell types.
See full target information EVX1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Advanced healthcare materials 14:e04817 PubMed40702833

2025

3D-Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Guebum Han,Nicolas S Lavoie,Nandadevi Patil,Olivia G Korenfeld,Hyunjun Kim,Manuel Esguerra,Daeha Joung,Michael C McAlpine,Ann M Parr

Molecular biology of the cell 35:ar144 PubMed39382837

2024

Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1.

Applications

Unspecified application

Species

Unspecified reactive species

Devin Frisby,Ajay B Murakonda,Bazella Ashraf,Kanika Dhawan,Leonardo Almeida-Souza,Naava Naslavsky,Steve Caplan

Molecular psychiatry 30:986-998 PubMed39227432

2024

Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models.

Applications

Unspecified application

Species

Unspecified reactive species

Giovanni Pietrogrande,Mohammed R Shaker,Sarah J Stednitz,Farhad Soheilmoghaddam,Julio Aguado,Sean D Morrison,Samuel Zambrano,Tahmina Tabassum,Ibrahim Javed,Justin Cooper-White,Thomas P Davis,Terence J O'Brien,Ethan K Scott,Ernst J Wolvetang
View all publications
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Product promise

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