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AB236382

Anti-Evx1 antibody [OTI1F8]

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(1 Publication)

Mouse Monoclonal EVX1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EVX1 aa 1-250.

View Alternative Names

Homeobox even-skipped homolog protein 1, EVX-1, EVX1

1 Images
Western blot - Anti-Evx1 antibody [OTI1F8] (AB236382)
  • WB

Supplier Data

Western blot - Anti-Evx1 antibody [OTI1F8] (AB236382)

All lanes:

Western blot - Anti-Evx1 antibody [OTI1F8] (ab236382) at 1/2000 dilution

Lane 1:

pCMV6-ENTRY control cDNA transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate at 5 µg

Lane 2:

pCMV6-ENTRY Evx1 cDNA transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate at 5 µg

Predicted band size: 42 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI1F8

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human EVX1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P49640

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from cell culture supernatant.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Evx1 also known as Even-Skipped Homeobox 1 acts as a transcription factor involved in multiple developmental processes. It belongs to the homeobox gene family and is characterized by a 43 kilodalton mass. Researchers have found Evx1 highly expressed in the embryonic tissue of vertebrates notably in motor neurons and dorsal neural tube regions during early stages of development. Its expression regulates patterns necessary for embryonic morphogenesis and differentiation.
Biological function summary

Evx1 plays a significant role in the regulation of genes essential for embryonic development particularly those involved in neural differentiation and segmentation. This protein interacts with other proteins and forms complexes that modulate gene expression needed for spinal cord development. By influencing the expression of important target genes Evx1 mediates processes important for proper neuronal identity and migration.

Pathways

Evx1 influences several key developmental pathways including the Wnt signaling and Notch signaling pathways. In the Wnt signaling pathway Evx1 interacts with the Wnt proteins to regulate gene transcription and ensure proper pattern formation. Similarly in the Notch signaling pathway Evx1 works alongside Notch proteins contributing to the cell fate decisions and segmental organization. These interactions highlight Evx1's integral role in the precise coordination of embryonic development.

Evx1 has associations with certain developmental abnormalities notably caudal dysgenesis and spina bifida. Such conditions often result from disruptions in normal Evx1 function affecting proper spinal cord formation. The target gene's association with the Wnt and Notch pathways along with proteins like β-catenin and Notch1 links it to these disorders highlighting its importance in maintaining developmental integrity and preventing pathological outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in the specification of neuronal cell types.
See full target information EVX1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Dose-response : a publication of International Hormesis Society 17:1559325819886766 PubMed31762715

2019

mRNA and lncRNA Expression Profiling of Radiation-Induced Gastric Injury Reveals Potential Radiation-Responsive Transcription Factors.

Applications

Unspecified application

Species

Unspecified reactive species

Guangxia Chen,Yang Feng,Zhiqiang Sun,Yiying Gao,Chuannan Wu,Haihan Zhang,Jinming Cao,Zhuo Chen,Jianping Cao,Yaqun Zhu,Shuyu Zhang
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