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AB23407

Anti-Exendin 4 antibody [20]

4

(1 Review)

|

(4 Publications)

Anti-Exendin 4 antibody [20] (ab23407) is a mouse monoclonal antibody detecting Exendin 4 in ELISA.

- Trusted since 2005

View Alternative Names

Exendin-4

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

20

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Applications

ELISA

applications

Epitope

The epitope is located in the region of amino acids 9 to 39 of exendin 4.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p>The antibody binds to exendin 4 when coated on ELISA wells and reacts specifically with exendin 4 in solution giving a Ka of 1.6 x 10E8 in an inhibition ELISA. The binding between ab23407 and exendin 4 is disrupted by 4.5 M MgCl2.</p>" } } }
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Product details

What is this antibody validated in?
Anti-Exendin 4 antibody [20] (ab23407) is a mouse monoclonal antibody and is validated for use in ELISA.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Exendin-4 also known as "exendine 4" or "exendin e 4" is a peptide with significant activity in glucose metabolism. The peptide originated from the saliva of the Gila monster Heloderma suspectum and has a molecular mass of approximately 4.2 kDa. It is expressed mainly in the pancreas but also found in other tissues. Exendin-4 acts as a potent agonist of the glucagon-like peptide-1 (GLP-1) receptor which is expressed in various parts of the body such as the brain and gastrointestinal tract.
Biological function summary

Exendin-4 enhances insulin secretion helping to regulate blood glucose levels effectively. It mimics the activity of GLP-1 which is involved in stimulating insulin release. Exendin-4 also slows gastric emptying and promotes satiety contributing to reduced food intake. Although the peptide does not form part of a larger complex its interactions directly affect multiple cellular processes relevant to metabolism.

Pathways

Exendin-4 participates in the insulin signaling and glucose homeostasis pathways. It influences insulin receptor substrate proteins thereby playing an important role in maintaining normal blood sugar levels. Exendin-4 modulates the activity of gluconeogenic enzymes connecting it to metabolic pathways involving energy balance and storage.

Exendin-4 shows relevance in treating type 2 diabetes and obesity. By enhancing insulin secretion and reducing appetite it provides therapeutic effects for individuals with diabetes. It shares functional characteristics with proteins like GLP-1 and insulin which are implicated in these metabolic disorders. Research continues to explore its potential benefits and application in managing these conditions more effectively.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
See full target information Exendin-4
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Brain : a journal of neurology 146:1821-1830 PubMed36907221

2023

The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial.

Applications

Unspecified application

Species

Unspecified reactive species

James L Mitchell,Hannah S Lyons,Jessica K Walker,Andreas Yiangou,Olivia Grech,Zerin Alimajstorovic,Nigel H Greig,Yazhou Li,Georgios Tsermoulas,Kristian Brock,Susan P Mollan,Alexandra J Sinclair

ACS sensors 7:784-789 PubMed35180342

2022

Electrochemical Sensing of the Peptide Drug Exendin-4 Using a Versatile Nucleic Acid Nanostructure.

Applications

Unspecified application

Species

Unspecified reactive species

Niamat Khuda,Subramaniam Somasundaram,Christopher J Easley

Journal of the American Chemical Society 142:1882-1894 PubMed31880439

2020

Directed Evolution Using Stabilized Bacterial Peptide Display.

Applications

Unspecified application

Species

Unspecified reactive species

Tejas Navaratna,Lydia Atangcho,Mukesh Mahajan,Vivekanandan Subramanian,Marshall Case,Andrew Min,Daniel Tresnak,Greg M Thurber

PloS one 11:e0165130 PubMed27764251

2016

Heterologous Expression and Delivery of Biologically Active Exendin-4 by Lactobacillus paracasei L14.

Applications

Unspecified application

Species

Unspecified reactive species

Zhu Zeng,Rui Yu,Fanglei Zuo,Bo Zhang,Deju Peng,Huiqin Ma,Shangwu Chen
View all publications
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Product promise

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