Anti-Exendin 4 antibody [20] (ab23407) is a mouse monoclonal antibody that is used to detect Exendin 4 in ELISA.
- Trusted since 2005
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 2.9% Sodium chloride, 0.0268% PBS
| ELISA | |
|---|---|
| Recombinant fragment | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant fragment | Dilution info - | Notes The antibody binds to exendin 4 when coated on ELISA wells and reacts specifically with exendin 4 in solution giving a Ka of 1.6 x 10E8 in an inhibition ELISA. The binding between ab23407 and exendin 4 is disrupted by 4.5 M MgCl2. |
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Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
Exendin-4
Anti-Exendin 4 antibody [20] (ab23407) is a mouse monoclonal antibody that is used to detect Exendin 4 in ELISA.
- Trusted since 2005
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 2.9% Sodium chloride, 0.0268% PBS
Exendin-4 also known as "exendine 4" or "exendin e 4" is a peptide with significant activity in glucose metabolism. The peptide originated from the saliva of the Gila monster Heloderma suspectum and has a molecular mass of approximately 4.2 kDa. It is expressed mainly in the pancreas but also found in other tissues. Exendin-4 acts as a potent agonist of the glucagon-like peptide-1 (GLP-1) receptor which is expressed in various parts of the body such as the brain and gastrointestinal tract.
Exendin-4 enhances insulin secretion helping to regulate blood glucose levels effectively. It mimics the activity of GLP-1 which is involved in stimulating insulin release. Exendin-4 also slows gastric emptying and promotes satiety contributing to reduced food intake. Although the peptide does not form part of a larger complex its interactions directly affect multiple cellular processes relevant to metabolism.
Exendin-4 participates in the insulin signaling and glucose homeostasis pathways. It influences insulin receptor substrate proteins thereby playing an important role in maintaining normal blood sugar levels. Exendin-4 modulates the activity of gluconeogenic enzymes connecting it to metabolic pathways involving energy balance and storage.
Exendin-4 shows relevance in treating type 2 diabetes and obesity. By enhancing insulin secretion and reducing appetite it provides therapeutic effects for individuals with diabetes. It shares functional characteristics with proteins like GLP-1 and insulin which are implicated in these metabolic disorders. Research continues to explore its potential benefits and application in managing these conditions more effectively.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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