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AB225679

Anti-Exfoliative Toxin A/ETA antibody

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(1 Publication)

Rabbit Polyclonal Exfoliative Toxin A/ETA antibody. Suitable for WB and reacts with Recombinant full length protein - Staphylococcus aureus samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Staphylococcus aureus eta.

View Alternative Names

Exfoliative toxin A, Epidermolytic toxin A, eta, Eta, Exfoliative toxin A, Epidermolytic toxin A

1 Images
Western blot - Anti-Exfoliative Toxin A/ETA antibody (AB225679)
  • WB

Supplier Data

Western blot - Anti-Exfoliative Toxin A/ETA antibody (AB225679)

All lanes:

Western blot - Anti-Exfoliative Toxin A/ETA antibody (ab225679) at 1/500 dilution

Lane 1:

Recombinant Staphylococcus aureus Exfoliative toxin A/ETA protein at 0.2 µg

Lane 2:

Recombinant Staphylococcus aureus Exfoliative toxin A/ETA protein at 0.1 µg

Lane 3:

Recombinant Staphylococcus aureus Exfoliative toxin A/ETA protein at 0.05 µg

Lane 4:

Recombinant Staphylococcus aureus Exfoliative toxin A/ETA protein at 0.025 µg

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 31 kDa

Observed band size: 32 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Staphylococcus aureus

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Staphylococcus aureus eta.

P09331

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Primary Antibodies

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Proteins & Peptides

AB236933

Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag)

Mass Spectrometry - Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) (AB236933)

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  • 0
Primary Antibodies

AB225681

Anti-50S ribosomal protein L7/L12 antibody

Western blot - Anti-50S ribosomal protein L7/L12 antibody (AB225681)

  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Staphylococcus aureus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" }, "Staphylococcus aureus": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Exfoliative Toxin A often referred to as ETA or exfoliative toxins is a powerful bacterial protease. Its molecular mass is approximately 27 kDa. Exfoliative Toxin A is expressed by Staphylococcus aureus particularly strains involved in skin infections. This toxin is known for cleaving desmoglein-1 a calcium-dependent cell adhesion molecule in the skin leading to epidermal detachment.
Biological function summary

Exfoliative toxins threaten the integrity of the skin barrier by targeting desmoglein-1 which compromises cellular adhesion within the epidermis. This specific action does not associate Exfoliative Toxin A with any larger protein complexes but rather with specialized pathways directly targeting epidermal cohesion. The cleavage of desmoglein-1 by ETA is significant in the pathogenic strategies of Staphylococcus aureus to cause skin exfoliation.

Pathways

Activities of Exfoliative Toxin A are integral to the pathogenesis of skin exfoliative conditions through the epidermal-dermal disruption pathway. This toxin associates with the serine protease family which modulates proteolytic pathways responsible for tissue damage and inflammation. Its action reverberates through pathways that involve proteins like desmoglein-1 emphasizing the complexity of cellular adhesion and skin integrity pathways.

Exfoliative toxin A exhibits a strong correlation with Staphylococcal Scalded Skin Syndrome (SSSS) and impetigo. These conditions are notable for their disruption of skin architecture and extensive blistering. Exfoliative Toxin A's interaction with desmoglein-1 plays a pivotal role in the pathophysiology of these diseases leading to significant epidermal peeling and vulnerability to secondary infections.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).
See full target information eta

Additional targets

Exfoliative Toxin A/ETA
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of physiology 603:5529-5545 PubMed40946331

2025

Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β-adrenergic signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Morten Hostrup,Lukas Moesgaard,Mads Fischer,Kate Aiko Wickham,Mads Pleshardt,Andreas Breenfeldt Andersen,Jacob Bejder,Martin Thomassen,Jens J Nielsen,Yvette Dehnes,Jens Bangsbo,Nikolai B Nordsborg,Søren Jessen
View all publications
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Product promise

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