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AB251853

Anti-EXOC1 antibody

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(4 Publications)

Rabbit Polyclonal EXOC1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EXOC1 aa 500-650.

View Alternative Names

SEC3, SEC3L1, BM-012, EXOC1, Exocyst complex component 1, Exocyst complex component Sec3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EXOC1 antibody (AB251853)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EXOC1 antibody (AB251853)

Paraffin-embedded human testis tissue stained for EXOC1 using ab251853 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-EXOC1 antibody (AB251853)
  • WB

Unknown

Western blot - Anti-EXOC1 antibody (AB251853)

All lanes:

Western blot - Anti-EXOC1 antibody (ab251853) at 0.4 µg/mL

All lanes:

RT4 (Human urinary bladder cancer cell line) cell lysate

Predicted band size: 102 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human EXOC1 aa 500-650. The exact immunogen used to generate this antibody is proprietary information.

Q9NV70

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EXOC1 also known as Exocyst Complex Component 1 is part of the exocyst complex which plays an essential role in vesicle trafficking. The protein works within a large complex that aids in the tethering of secretory vesicles to specific areas of the plasma membrane before fusion. EXOC1 consists of 97 kDa and is the component of the exocyst complex expressed in numerous tissues with high expression in the brain and liver.
Biological function summary

The exocyst complex supports protein and lipid distribution at the cell surface which influences cell signaling growth and differentiation. EXOC1 as a component of this complex contributes to orchestrated membrane dynamics. The exocyst complex includes other proteins such as EXOC3 EXOC4 and SEC10 and together it achieves targeted delivery of vesicles which is necessary for cellular expansion.

Pathways

The exocyst complex including EXOC1 is involved in the exocytosis pathway where it supports the transport of vesicles from the Golgi to the plasma membrane. This protein plays a role alongside small GTPases notably Rho and Rab which regulate vesicular trafficking. EXOC1 associates with the mTOR signaling pathway where it influences cellular growth and metabolism through its role in vesicle targeting.

EXOC1 is linked with conditions such as cancer and diabetes. Its role in vesicle trafficking implicates it in tumor progression where alterations in exocyst complex components disrupt cellular secretion and promote cancerous behaviors. The involvement in the mTOR pathway associates EXOC1 with metabolic disorders such as type 2 diabetes where dysfunctional signaling affects insulin response. Changes in expression levels or mutations in EXOC1 can influence disease states affecting proteins like Rho GTPases within these complexes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.. (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation.
See full target information EXOC1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature cancer 6:1714-1733 PubMed40877413

2025

MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Cangkrama,Huan Liu,Xiaoyu Wu,Josephine Yates,James Whipman,Christoph G Gäbelein,Mai Matsushita,Luca Ferrarese,Sibilla Sander,Francesc Castro-Giner,Simran Asawa,Magdalena K Sznurkowska,Manfred Kopf,Jörn Dengjel,Valentina Boeva,Nicola Aceto,Julia A Vorholt,Sabine Werner

eLife 13: PubMed39960487

2025

Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape.

Applications

Unspecified application

Species

Unspecified reactive species

Ashley L Cook,Surojit Sur,Laura Dobbyn,Evangeline Watson,Joshua D Cohen,Blair Ptak,Bum Seok Lee,Suman Paul,Emily Hsiue,Maria Popoli,Bert Vogelstein,Nickolas Papadopoulos,Chetan Bettegowda,Kathy Gabrielson,Shibin Zhou,Kenneth W Kinzler,Nicolas Wyhs

Cell biology international 47:188-200 PubMed36183369

2022

HELQ suppresses migration and proliferation of non-small cell lung cancer cells by repairing DNA damage and inducing necrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Shan Zhong,Wei Lai Tong,Yu Zhang,Shi Ning Xiao,Jia Ming Liu,An An Li,Ge Liang Yao,Qing Lin,Zhi Li Liu

American journal of translational research 11:5162-5169 PubMed31497231

2019

lncRNA SNHG20 promotes prostate cancer migration and invasion via targeting the miR-6516-5p/SCGB2A1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xingcheng Wu,Yu Xiao,Yi Zhou,Zhien Zhou,Weigang Yan
View all publications
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