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AB118792

Anti-EXOC7 antibody

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(4 Publications)

Rabbit Polyclonal EXOC7 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human EXOC7 aa 1-50.

View Alternative Names

EXO70, KIAA1067, EXOC7, Exocyst complex component 7, Exocyst complex component Exo70

2 Images
Immunoprecipitation - Anti-EXOC7 antibody (AB118792)
  • IP

Unknown

Immunoprecipitation - Anti-EXOC7 antibody (AB118792)

Detection of EXOC7 in Immunoprecipitates of HeLa whole cell lysates (1 mg for IP, 20% of IP loaded) using ab118792 at 6 µg/mg lysate for IP and at 1 µg/ml for subsequent Western blot detection.
Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-EXOC7 antibody (ab118792)

Predicted band size: 83 kDa

false

Western blot - Anti-EXOC7 antibody (AB118792)
  • WB

Unknown

Western blot - Anti-EXOC7 antibody (AB118792)

All lanes:

Western blot - Anti-EXOC7 antibody (ab118792) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

293T whole cell lysate at 50 µg

Lane 4:

Jurkat whole cell lysate at 50 µg

Lane 5:

NIH3T3 whole cell lysate at 50 µg

Predicted band size: 83 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human EXOC7 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9UPT5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Elephant": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EXOC7 also known as Exocyst Complex Component 7 is a part of the exocyst complex involved in the regulation of vesicle trafficking. This protein weighs approximately 76 kDa and functions by facilitating the fusion of vesicles with the plasma membrane. It is generally expressed in various tissue types but shows higher levels in lung and brain tissues. EXOC7 often works with other components of the exocyst complex to carry out its role in cellular trafficking.
Biological function summary

EXOC7 plays a significant role in exocyst-mediated processes acting as a critical component of the exocyst complex. This multi-protein complex is essential for targeting secretory vesicles to specific docking sites in the plasma membrane. EXOC7 is involved in processes like cell polarity migration and even in the maintenance of tight junctions. Through its interactions with other exocyst components it aids in the spatial organization of the cell influencing overall cellular architecture and functionality.

Pathways

EXOC7 integrates into exocytosis and cell signaling pathways. It particularly plays a role in the exocytosis pathway which is essential for secretion and cell-surface receptor recycling. EXOC7 interacts with other exocyst complex proteins such as SEC10 and SEC15 promoting efficient vesicle tethering and fusion events. Additionally it links to the ARF6-dependent pathways that affect actin cytoskeleton remodeling demonstrating its importance in cell movement and structural remodeling.

EXOC7's proper function is essential for normal cellular processes and its dysregulation has connections to type 2 diabetes and certain cancers. In type 2 diabetes misregulated exocyst complex activities including those involving EXOC7 can disrupt insulin secretion. In cancer altered expression or function of the exocyst complex may contribute to metastasis due to its role in cell adhesion and migration. EXOC7's interaction with other proteins such as EXOC3L1 and EXOC5 could play a significant role in these disease mechanisms highlighting its potential as a target for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity).
See full target information EXOC7
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancers 16: PubMed38254825

2024

Exo70 Promotes the Invasion of Pancreatic Cancer Cells via the Regulation of Exosomes.

Applications

Unspecified application

Species

Unspecified reactive species

Jingzhou Xiang,Bowen Zheng,Lingying Zhao,Yuting He,Fanzhuoran Lou,Runyang Li,Miao Fu,Xintian Huang,Wenqing Zhang,Xiaoting Hong,Li Xiao,Tianhui Hu

Molecular neurobiology 59:4854-4868 PubMed35641779

2022

LncRNA MIAT Promotes Spinal Cord Injury Recovery in Rats by Regulating RBFOX2-Mediated Alternative Splicing of MCL-1.

Applications

Unspecified application

Species

Unspecified reactive species

Xin He,Jianan Zhang,Yunshan Guo,Xiaowei Yang,Yunfei Huang,Dingjun Hao

Cell metabolism 33:2367-2379.e4 PubMed34767745

2021

Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin.

Applications

Unspecified application

Species

Unspecified reactive species

David G Le Couteur,Samantha M Solon-Biet,Benjamin L Parker,Tamara Pulpitel,Amanda E Brandon,Nicholas J Hunt,Jibran A Wali,Rahul Gokarn,Alistair M Senior,Gregory J Cooney,David Raubenheimer,Victoria C Cogger,David E James,Stephen J Simpson

Genetics in medicine : official journal of the Ame 22:1040-1050 PubMed32103185

2020

Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival.

Applications

Unspecified application

Species

Unspecified reactive species

Michael E Coulter,Damir Musaev,Ellen M DeGennaro,Xiaochang Zhang,Katrin Henke,Kiely N James,Richard S Smith,R Sean Hill,Jennifer N Partlow, Muna Al-Saffar,A Stacy Kamumbu,Nicole Hatem,A James Barkovich,Jacqueline Aziza,Nicolas Chassaing,Maha S Zaki,Tipu Sultan,Lydie Burglen,Anna Rajab,Lihadh Al-Gazali,Ganeshwaran H Mochida,Matthew P Harris,Joseph G Gleeson,Christopher A Walsh
View all publications
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