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AB225684

Anti-Exopolyphosphatase antibody

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(3 Publications)

Rabbit Polyclonal Exopolyphosphatase antibody. Suitable for WB and reacts with Recombinant full length protein - Saccharomyces cerevisiae samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Saccharomyces cerevisiae S288C PPX1.

View Alternative Names

YHR201C, PPX1, Polyphosphatase, PolyPase, Exopolyphosphatase, Metaphosphatase

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Saccharomyces cerevisiae

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Saccharomyces cerevisiae S288C PPX1.

P38698

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Primary Antibodies

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Anti-Saccharomyces cerevisiae antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Saccharomyces cerevisiae": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" }, "Saccharomyces cerevisiae": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Exopolyphosphatase often referred to as PPX functions to degrade inorganic polyphosphates by cleaving terminal phosphate residues. This enzyme facilitates the hydrolysis of polyphosphate chains resulting in shorter phosphates and inorganic phosphate. With a molecular mass around 64 kDa exopolyphosphatase locates itself mainly in the cytoplasm. Studies report its expression in a variety of organisms including bacteria yeast and mammals where it plays a significant role in phosphate metabolism.
Biological function summary

Exopolyphosphatase helps regulate intracellular levels of inorganic polyphosphate which acts as a reservoir of energy and phosphate involved in stress response and cellular processes like cation sequestration. Exopolyphosphatase can act as part of larger enzymatic complexes functioning with other polyphosphate-related enzymes. This regulatory function is important for maintaining cellular homoeostasis and supports different cellular responses.

Pathways

Exopolyphosphatase plays an important role in phosphate turnover and energy metabolism pathways. It influences the synthesis and breakdown of polyphosphate chains which ties into the phosphate regulon and other metabolic pathways related to phosphate economy. It works in association with proteins like polyphosphate kinase which synthesizes polyphosphates creating a balance within the phosphate regulatory network.

Altered exopolyphosphatase activity can link to bacterial pathogenesis and human disorders of phosphate metabolism. Disruptions in its function associate with conditions like osteochondrodysplasia due to imbalanced phosphate levels affecting bone metabolism. Additionally its activity impacts proteins involved in infection processes such as those affecting bacterial virulence making it a target for antimicrobial research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Polyphosphatase (polyPase) involved in the degradation of inorganic polyphosphates (polyP) that is able to degrade a range of chains from three to several hundreds of residues in a highly processive manner (PubMed : 7860598). Exclusively shows exopolyphosphatase activity, cleaving inside the polyP chain (PubMed : 31175919).
See full target information PPX1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7231 PubMed40769975

2025

Antimicrobial peptide class that forms discrete β-barrel stable pores anchored by transmembrane helices.

Applications

Unspecified application

Species

Unspecified reactive species

Seth W Dickey,Dylan J Burgin,Ama N Antwi,Amer Villaruz,Madeline R Galac,Gordon Y C Cheung,Tatiana K Rostovtseva,Liam J Worrall,Aleksander C Lazarski,Elio A Cino,D Peter Tieleman,Sergey M Bezrukov,Natalie C J Strynadka,Michael Otto

Molecular metabolism 91:102077 PubMed39617267

2024

Mammalian mitochondrial inorganic polyphosphate (polyP) and cell signaling: Crosstalk between polyP and the activity of AMPK.

Applications

Unspecified application

Species

Unspecified reactive species

Renata T Da Costa,Anna Nichenko,Matheus M Perez,Malgorzata Tokarska-Schlattner,Sheida Kavehmoghaddam,Vedangi Hambardikar,Ernest R Scoma,Erin L Seifert,Uwe Schlattner,Joshua C Drake,Maria E Solesio

The Journal of biological chemistry 295:1439-1451 PubMed31844018

2019

Development of a yeast model to study the contribution of vacuolar polyphosphate metabolism to lysine polyphosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Cristina Azevedo,Yann Desfougères,Yannasittha Jiramongkol,Hamish Partington,Sasanan Trakansuebkul,Jyoti Singh,Nicole Steck,Henning J Jessen,Adolfo Saiardi
View all publications
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Product promise

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