Anti-EYA3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

EYA3 also known as Eyes Absent Homolog 3 is a protein with a mass of approximately 65 kDa. It performs a dual function serving as both a phosphatase and a transcriptional co-activator. EYA3 exhibits expression in various tissues including the brain kidney and muscle. This protein plays an important mechanical role in the complex regulation of developmental and cellular processes influencing critical activities inside cells.

Biological function summary

EYA3 functions in conjunction with other members of the EYA protein family. It associates with the SIX family of transcription factors acting as part of a protein complex. This complex significantly impacts the regulation of gene expression during development especially in organogenesis. The protein's role becomes particularly apparent during the development of organs such as the eyes where it influences cellular differentiation and morphogenesis.

Pathways

The activity of EYA3 integrates into two significant signaling cascades: the Wnt signaling pathway and the Hedgehog signaling pathway. EYA3 interacts with relevant proteins within these pathways such as beta-catenin in the Wnt pathway and Gli proteins in the Hedgehog pathway. These interactions allow EYA3 to participate actively in cellular proliferation differentiation and apoptosis.

Associated diseases and disorders

EYA3 expression links to several significant conditions including cancer and specifically breast cancer. Altered expression levels of EYA3 have been observed in tumor cells where they may affect the behavior of cancer cells. Additionally its relationship with proteins such as p53 a tumor suppressor highlights its potential impact on cancer development and progression. Understanding EYA3's role could provide insights into therapeutic strategies for targeting such diseases.