Goat Polyclonal EYA4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human EYA4 aa 1-50.
Images
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human EYA4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link O95677
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 3.75 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).
Alternative names
Eyes absent homolog 4, EYA4
Recommended products
Goat Polyclonal EYA4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human EYA4 aa 1-50.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human EYA4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link O95677
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
EYA4 also known as Eyes Absent 4 is a protein involved in several important cellular processes. It has an approximate molecular mass of 64 kDa. This protein acts as a phosphatase removing phosphate groups from specific proteins. EYA4 is expressed in various tissues including the heart brain and kidneys. Its presence in these diverse tissues indicates its importance in multiple cellular functions.
- Biological function summary
EYA4 contributes to the DNA damage repair process and is important for normal cellular development and function. The protein exists as part of a transcriptional complex often interacting with other proteins to regulate gene expression. This interaction suggests a role in cellular differentiation and proliferation supporting healthy developmental processes and maintaining cell health over time.
- Pathways
EYA4 plays an integral role in the Notch signaling and DNA repair pathways. In the Notch signaling pathway it associates with the transcription co-activator protein YAP to influence cell fate decisions. This involvement highlights its importance in cellular architecture maintenance. Its function in the DNA repair pathway further links it with the ATM protein coordinating effective responses to genomic stress and preserving genomic integrity.
- Associated diseases and disorders
Alterations in EYA4 expression or function can contribute to sensorineural hearing loss and certain types of cancer including breast cancer. Defective EYA4 interactions with the protein SIX1 have been linked to hearing impairments. In cancer biology aberrant EYA4 function may disrupt its DNA repair capability facilitating genomic instability and tumor progression indicating a critical role in maintaining cellular homeostasis and preventing disease.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (ab110148)
ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human liver by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (ab110148)
ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human testis by Immunohistochemistry.
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