Anti-Ezrin / Radixin / Moesin antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Ezrin Radixin and Moesin play important roles in cellular morphology motility and adhesion impacting signal transduction processes. These proteins do not operate singularly; they form and function as part of larger complexes that regulate cell surface structures and dynamics. ERM proteins dynamically associate and dissociate from cellular membranes facilitating the assembly and disassembly of membrane domains. By regulating microvilli structure their activity directly affects processes like nutrient absorption and pathogen defense in epithelial cells.

Pathways

Ezrin Radixin and Moesin participate in organizing various signal transduction pathways notably the Rho and Ras signaling pathways. These pathways influence cell motility proliferation and survival. The ERM proteins interact with regulatory molecules such as Rho GTPases and integrate signals from membrane receptors to coordinate cytoskeletal reorganization. Their association with the Ras pathway helps modulate growth factor signaling linking membrane dynamics to cell growth and differentiation processes.