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AB137927

Anti-F2RL3 antibody

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(3 Publications)

Rabbit Polyclonal F2RL3 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human F2RL3.

View Alternative Names

PAR4, F2RL3, Proteinase-activated receptor 4, PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3

1 Images
Western blot - Anti-F2RL3 antibody (AB137927)
  • WB

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Western blot - Anti-F2RL3 antibody (AB137927)

All lanes:

Western blot - Anti-F2RL3 antibody (ab137927) at 1/500 dilution

All lanes:

HT29 cell lysate at 30 µg

Predicted band size: 41 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human F2RL3. The exact immunogen used to generate this antibody is proprietary information.

Q96RI0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab137927 was affinity purified from Rabbit antiserum by immunogenic peptide affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

F2RL3 also known as Protease-activated receptor 4 (PAR-4) is a G-protein coupled receptor with a molecular mass of approximately 42 kDa. This protein plays an important role in cellular responses to extracellular signals and is important for thrombin signaling in platelets. F2RL3 is expressed in a variety of tissues including the platelets vascular smooth muscle cells and endothelial cells. The receptor gets activated by proteolytic cleavage by thrombin and other proteases leading to a sequence of intracellular signaling events.
Biological function summary

F2RL3 is a significant component in coagulation and inflammatory response processes. The receptor participates in platelet activation and aggregation which contributes to blood clotting. F2RL3 forms part of a complex that includes other protease-activated receptors facilitating precise regulation of vascular function and homeostasis. The receptor also contributes to inflammation through interactions with immune cells impacting vascular and tissue inflammation.

Pathways

The function of F2RL3 integrates into the coagulation cascade and inflammatory signaling pathways. It interacts with other proteins like thrombin and F2RL1 (PAR-1) mediating platelet aggregation and extension of thrombotic processes. Through its action in pathways involving thrombin F2RL3 ensures effective hemostasis and also contributes to signaling pathways that mediate inflammation and tissue repair.

F2RL3 has a relationship with thrombotic disorders and atherosclerosis. Abnormal activation or expression of F2RL3 can lead to excessive platelet activation increasing the risk of thrombosis. Furthermore its role in inflammatory pathways implies a connection to atherosclerosis a condition characterized by inflammation and plaque buildup in arteries. The receptor interacts with proteins such as PAR-1 during these disease processes which contributes to the pathophysiology of thrombotic and cardiovascular conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed : 10079109). May play a role in platelets activation (PubMed : 10079109).
See full target information F2RL3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Brain sciences 13: PubMed37371401

2023

Electroacupuncture Relieves Visceral Hypersensitivity via Balancing PAR2 and PAR4 in the Descending Pain Modulatory System of Goats.

Applications

Unspecified application

Species

Unspecified reactive species

Panpan Guo,Qiulin Zhang,Sha Nan,Haolong Wang,Ning Ma,Faisal Ayub Kiani,Mingxing Ding,Jianguo Chen

Frontiers in pharmacology 12:756632 PubMed35002698

2021

Targeting Proteinase Activated Receptor-4 Reduces Mechanonociception During the Acute Inflammatory Phase but not the Chronic Neuropathic Phase of Osteoarthritis in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa S O'Brien,Jason J McDougall

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:9432-40 PubMed25009274

2014

Presynaptic inhibition by α2 receptor/adenylate cyclase/PDE4 complex at retinal rod bipolar synapse.

Applications

Unspecified application

Species

Unspecified reactive species

Cun-Jian Dong,Yuanxing Guo,Yilin Ye,William A Hare
View all publications
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