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AB150551

Anti-F2RL3 antibody

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(1 Publication)

Rabbit Polyclonal F2RL3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human F2RL3.

View Alternative Names

PAR4, F2RL3, Proteinase-activated receptor 4, PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-F2RL3 antibody (AB150551)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-F2RL3 antibody (AB150551)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung, respiratory epithelium, tissue, labeling F2RL3 with ab150551 at 10 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human F2RL3. The exact immunogen used to generate this antibody is proprietary information.

Q96RI0

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10-25 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

F2RL3 also known as Protease-activated receptor 4 (PAR-4) is a G-protein coupled receptor with a molecular mass of approximately 42 kDa. This protein plays an important role in cellular responses to extracellular signals and is important for thrombin signaling in platelets. F2RL3 is expressed in a variety of tissues including the platelets vascular smooth muscle cells and endothelial cells. The receptor gets activated by proteolytic cleavage by thrombin and other proteases leading to a sequence of intracellular signaling events.
Biological function summary

F2RL3 is a significant component in coagulation and inflammatory response processes. The receptor participates in platelet activation and aggregation which contributes to blood clotting. F2RL3 forms part of a complex that includes other protease-activated receptors facilitating precise regulation of vascular function and homeostasis. The receptor also contributes to inflammation through interactions with immune cells impacting vascular and tissue inflammation.

Pathways

The function of F2RL3 integrates into the coagulation cascade and inflammatory signaling pathways. It interacts with other proteins like thrombin and F2RL1 (PAR-1) mediating platelet aggregation and extension of thrombotic processes. Through its action in pathways involving thrombin F2RL3 ensures effective hemostasis and also contributes to signaling pathways that mediate inflammation and tissue repair.

F2RL3 has a relationship with thrombotic disorders and atherosclerosis. Abnormal activation or expression of F2RL3 can lead to excessive platelet activation increasing the risk of thrombosis. Furthermore its role in inflammatory pathways implies a connection to atherosclerosis a condition characterized by inflammation and plaque buildup in arteries. The receptor interacts with proteins such as PAR-1 during these disease processes which contributes to the pathophysiology of thrombotic and cardiovascular conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed : 10079109). May play a role in platelets activation (PubMed : 10079109).
See full target information F2RL3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncoimmunology 6:e1359450 PubMed29147624

2017

High CXC chemokine receptor 1 level represents an independent negative prognosticator in non-metastatic clear-cell renal cell carcinoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Zhu,Zheng Liu,Yiwei Wang,Hangcheng Fu,Zewei Wang,Huyang Xie,Junyu Zhang,Gaoxiang Li,Bo Dai,Dingwei Ye,Jiejie Xu
View all publications
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Product promise

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