Rabbit Polyclonal F2RL3 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human F2RL3.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human F2RL3. The exact immunogen used to generate this antibody is proprietary information. Database link Q96RI0
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Monkey | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10.00000-25.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Monkey | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109).
Alternative names
PAR4, F2RL3, Proteinase-activated receptor 4, PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3
Recommended products
Rabbit Polyclonal F2RL3 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human F2RL3.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human F2RL3. The exact immunogen used to generate this antibody is proprietary information. Database link Q96RI0
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
F2RL3 also known as Protease-activated receptor 4 (PAR-4) is a G-protein coupled receptor with a molecular mass of approximately 42 kDa. This protein plays an important role in cellular responses to extracellular signals and is important for thrombin signaling in platelets. F2RL3 is expressed in a variety of tissues including the platelets vascular smooth muscle cells and endothelial cells. The receptor gets activated by proteolytic cleavage by thrombin and other proteases leading to a sequence of intracellular signaling events.
- Biological function summary
F2RL3 is a significant component in coagulation and inflammatory response processes. The receptor participates in platelet activation and aggregation which contributes to blood clotting. F2RL3 forms part of a complex that includes other protease-activated receptors facilitating precise regulation of vascular function and homeostasis. The receptor also contributes to inflammation through interactions with immune cells impacting vascular and tissue inflammation.
- Pathways
The function of F2RL3 integrates into the coagulation cascade and inflammatory signaling pathways. It interacts with other proteins like thrombin and F2RL1 (PAR-1) mediating platelet aggregation and extension of thrombotic processes. Through its action in pathways involving thrombin F2RL3 ensures effective hemostasis and also contributes to signaling pathways that mediate inflammation and tissue repair.
- Associated diseases and disorders
F2RL3 has a relationship with thrombotic disorders and atherosclerosis. Abnormal activation or expression of F2RL3 can lead to excessive platelet activation increasing the risk of thrombosis. Furthermore its role in inflammatory pathways implies a connection to atherosclerosis a condition characterized by inflammation and plaque buildup in arteries. The receptor interacts with proteins such as PAR-1 during these disease processes which contributes to the pathophysiology of thrombotic and cardiovascular conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-F2RL3 antibody (ab150551)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung, respiratory epithelium, tissue, labeling F2RL3 with ab150551 at 10 μg/ml.
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