AB188930

Anti-F2RL3 antibody - N-terminal

Name: Anti-F2RL3 antibody - N-terminal (ab188930) | Abcam
Brand: Abcam Limited
SKU: AB188930

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(2 Publications)

Rabbit Polyclonal F2RL3 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human F2RL3.

View Alternative Names

PAR4, F2RL3, Proteinase-activated receptor 4, PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-F2RL3 antibody - N-terminal (AB188930)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-F2RL3 antibody - N-terminal (AB188930)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung (respiratory epithelium) tissue labeling F2RL3 with ab188930 at 13 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human F2RL3. The exact immunogen used to generate this antibody is proprietary information.

Q96RI0

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "6-13 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

F2RL3 also known as Protease-activated receptor 4 (PAR-4) is a G-protein coupled receptor with a molecular mass of approximately 42 kDa. This protein plays an important role in cellular responses to extracellular signals and is important for thrombin signaling in platelets. F2RL3 is expressed in a variety of tissues including the platelets vascular smooth muscle cells and endothelial cells. The receptor gets activated by proteolytic cleavage by thrombin and other proteases leading to a sequence of intracellular signaling events.

Biological function summary

F2RL3 is a significant component in coagulation and inflammatory response processes. The receptor participates in platelet activation and aggregation which contributes to blood clotting. F2RL3 forms part of a complex that includes other protease-activated receptors facilitating precise regulation of vascular function and homeostasis. The receptor also contributes to inflammation through interactions with immune cells impacting vascular and tissue inflammation.

Pathways

The function of F2RL3 integrates into the coagulation cascade and inflammatory signaling pathways. It interacts with other proteins like thrombin and F2RL1 (PAR-1) mediating platelet aggregation and extension of thrombotic processes. Through its action in pathways involving thrombin F2RL3 ensures effective hemostasis and also contributes to signaling pathways that mediate inflammation and tissue repair.

F2RL3 has a relationship with thrombotic disorders and atherosclerosis. Abnormal activation or expression of F2RL3 can lead to excessive platelet activation increasing the risk of thrombosis. Furthermore its role in inflammatory pathways implies a connection to atherosclerosis a condition characterized by inflammation and plaque buildup in arteries. The receptor interacts with proteins such as PAR-1 during these disease processes which contributes to the pathophysiology of thrombotic and cardiovascular conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed : 10079109). May play a role in platelets activation (PubMed : 10079109).

See full target information F2RL3

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Naunyn-Schmiedeberg's archives of pharmacology 397:7187-7200 PubMed38652276

2024

The thrombin receptor PAR4 supports visceral adipose tissue inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Sonja Kleeschulte,Vivien Fischinger,Lisa Öhlke,Johannes Bode,Markus Kamler,Dobromir Dobrev,Maria Grandoch,Anke C Fender

Cellular signalling 52:147-154 PubMed30213686

2018

Ligand-mediated dephosphorylation signaling for MAP kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Nataliia V Shults,Faisal S Almansour,Vladyslava Rybka,Dante I Suzuki,Yuichiro J Suzuki

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-F2RL3 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-F2RL3 antibody - N-terminal (AB188930)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise