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AB13979

Anti-FABP4 antibody

4

(2 Reviews)

|

(48 Publications )

Rabbit Polyclonal FABP4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 48 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FABP4.
4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody (AB13979)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody (AB13979)

Immunohistochemical analysis of FFPE human adipose tissue, labeling FABP4 with ab13979 (2μg/ml). DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody (AB13979)
  • IHC-P

PubMed

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody (AB13979)

Immunohistochemical analysis of Human carotid atherosclerotic plaques, staining FABP4 with ab13979.

Antigen retrieval was performed by heat mediation in a citrate buffer (pH 6) and blocked with 0.5% BSA. Sections were incubated with primary antibody for 1 hour at room temperature. Staining was detected using DAB.

Image from Holm S et al., PLoS One. 2011;6(12):e28785. Epub 2011 Dec 9. Fig 3.; doi:10.1371/journal.pone.0028785; December 9, 2011, PLoS ONE 6(12): e28785.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody (AB13979)
  • IHC-P

PubMed

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody (AB13979)

Immunohistochemical analysis of Human carotid atherosclerotic plaques, staining FABP4 with ab13979.

Antigen retrieval was performed by heat mediation in a citrate buffer (pH 6) and blocked with 0.5% BSA. Sections were incubated with primary antibody for 1 hour at room temperature. An AlexaFluor®488-conjugated goat anti-rabbit IgG was used as the secondary antibody.

Image from Holm S et al., PLoS One. 2011;6(12):e28785. Epub 2011 Dec 9. Fig 3.; doi:10.1371/journal.pone.0028785; December 9, 2011, PLoS ONE 6(12): e28785.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody (AB13979)
  • IHC-P

AbReview20068****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody (AB13979)

Immunohistochemical analysis of FFPE mouse pancreatic and peri-pancreatic fatty tissue, labeling FABP4 with ab13979. Tissue was fixed in 10% neutral buffered formalin, heat mediated antigen retrieval was performed using citrate buffer, and blocking was performed with 10% goat serum and 1% BSA inj TBST for 1 hour at 25°C.

Staining with ab13979 (diluted 1/500) was performed for 12 hours at 4°C. A goat anti-rabbit HRP-conjugated secondary was used, diluted 1/200.

This image is courtesy of an anonymous Abreview.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FABP4.

P15090

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200", "IHCP-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Constituents: PBS, 0.58% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fatty acid-binding protein 4 (FABP4) also known as aP2 is a member of the fatty acid-binding protein family. It predominantly exists in adipocytes and macrophages serving an important role in lipid metabolism and transport. FABP4 facilitates the binding and transport of long-chain fatty acids and other hydrophobic molecules within cells. The molecular weight of FABP4 is approximately 14-15 kDa. It exhibits high expression levels in adipose tissue and is inducible in macrophages under certain conditions.
Biological function summary

This protein participates in the regulation of lipid homeostasis and energy metabolism. FABP4 is part of the lipid-binding protein family that helps maintain fatty acid equilibrium within cells. By controlling the transport and signaling of lipids FABP4 impacts lipid storage insulin sensitivity and inflammation processes. Its activity is not confined to a specific multimeric complex yet it interacts with other proteins to exert its functions contributing to significant metabolic pathways in the body.

Pathways

FABP4 plays essential roles in the regulation of metabolic and inflammatory signaling pathways. It is intricately involved in the peroxisome proliferator-activated receptor gamma (PPARγ) pathway where it modulates adipose tissue development and glucose metabolism. In addition FABP4 has connections with the c-Jun N-terminal kinase (JNK) signaling pathway influencing stress and inflammatory responses. Interactions with these pathways place FABP4 at a link with proteins like PPARγ and JNK essential for cellular metabolic balance and responses to metabolic stress.

Researchers connect FABP4 to conditions such as obesity and type 2 diabetes. Its expression levels correlate with insulin resistance and metabolic syndrome making it a target of interest in these metabolic disorders. FABP4 interacts with other proteins like adiponectin which is important in modulating glucose levels and fatty acid breakdown. Understanding FABP4's role in these pathways can facilitate the development of therapeutic strategies aimed at targeting metabolic dysfunctions associated with obesity and diabetes.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
See full target information FABP4

Alternative Names

Adipocyte lipid-binding protein, Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, ALBP, A-FABP, AFABP, FABP4

Publications (48)

Recent publications for all applications. Explore the full listand refine your search

Lipids in health and disease 24:239 PubMed40660209

2025

Lipid infiltration promotes trans-differentiation of vascular smooth muscle cells into macrophage-like cells in early lesions of human coronary atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Junhai Hao,Jiang Liu,Jiahui Zhou,Yuanfeng Liang,Wanwen Chen,Yueheng Wu,Zhanyi Lin

Nature cardiovascular research 4:921-937 PubMed40579458

2025

Mechanosensitive PIEZO2 channels shape coronary artery development.

Applications

Unspecified application

Species

Unspecified reactive species

Mireia Pampols-Perez,Carina Fürst,Oscar Sánchez-Carranza,Elena Cano,Jonathan Alexis Garcia-Contreras,Lisa Mais,Wenhan Luo,Sandra Raimundo,Eric L Lindberg,Martin Taube,Arnd Heuser,Anje Sporbert,Dagmar Kainmueller,Miguel O Bernabeu,Norbert Hübner,Holger Gerhardt,Gary R Lewin,Annette Hammes

International journal of molecular sciences 26: PubMed40429934

2025

Fatty Acid Metabolism Regulators Have Pivotal Roles in the Pathogenesis of Ovarian Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Megumi Watanabe,Motoki Matsuura,Tatsuya Sato,Makoto Usami,Tsuyoshi Saito,Masato Furuhashi,Kohichi Takada,Hiroshi Ohguro

Nature cell biology 26:2020-2034 PubMed39528700

2024

Specialized post-arterial capillaries facilitate adult bone remodelling.

Applications

Unspecified application

Species

Unspecified reactive species

Vishal Mohanakrishnan,Kishor K Sivaraj,Hyun-Woo Jeong,Esther Bovay,Backialakshmi Dharmalingam,M Gabriele Bixel,Van Vuong Dinh,Milena Petkova,Isidora Paredes Ugarte,Yi-Tong Kuo,Malarvizhi Gurusamy,Brian Raftrey,Nelson Tsz Long Chu,Soumyashree Das,Pamela E Rios Coronado,Martin Stehling,Lars Sävendahl,Andrei S Chagin,Taija Mäkinen,Kristy Red-Horse,Ralf H Adams

Scientific reports 14:15390 PubMed38965292

2024

Concomitant decrease of E- and A-FABP expression predicts worse survival in urothelial bladder cancer patients.

Applications

Unspecified application

Species

Unspecified reactive species

Inès Saizonou,Isabelle Lascombe,Franck Monnien,Isabelle Bedgedjian,François Kleinclauss,Marie-Paule Algros,Sylvie Fauconnet

BMC cancer 24:65 PubMed38216952

2024

SARIFA as a new histopathological biomarker is associated with adverse clinicopathological characteristics, tumor-promoting fatty-acid metabolism, and might predict a metastatic pattern in pT3a prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Johanna S Enke,Matthias Groß,Bianca Grosser,Eva Sipos,Julie Steinestel,Phillip Löhr,Johanna Waidhauser,Constantin Lapa,Bruno Märkl,Nic G Reitsam

Experimental & molecular medicine 55:1520-1530 PubMed37394587

2023

Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Jung-Hwan Baek,Myung Sup Kim,Hye Ryeon Jung,Min-Seon Hwang,Chan-Ho Lee,Dai Hoon Han,Yong-Ho Lee,Eugene C Yi,Seung-Soon Im,Ilseon Hwang,Kyungeun Kim,Joon-Yong Chung,Kyung-Hee Chun

Frontiers in cellular and infection microbiology 13:1161669 PubMed37153157

2023

An humanized model to study homing and sequestration of transmission stages in the bone marrow.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha Donsante,Giulia Siciliano,Mariagrazia Ciardo,Biagio Palmisano,Valeria Messina,Valeria de Turris,Giorgia Farinacci,Marta Serafini,Francesco Silvestrini,Alessandro Corsi,Mara Riminucci,Pietro Alano

Frontiers in endocrinology 13:882379 PubMed35757418

2022

Morphological and Immunophenotypical Changes of Human Bone Marrow Adipocytes in Marrow Metastasis and Myelofibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Michele Dello Spedale Venti,Biagio Palmisano,Samantha Donsante,Giorgia Farinacci,Flavia Adotti,Ilenia Coletta,Marta Serafini,Alessandro Corsi,Mara Riminucci

Theranostics 12:1904-1920 PubMed35198079

2022

The peroxisome proliferator-activated receptor agonist rosiglitazone specifically represses tumour metastatic potential in chromatin inaccessibility-mediated FABP4-deficient gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qi-Yue Chen,Xiao-Bo Huang,Ya-Jun Zhao,Hua-Gen Wang,Jia-Bin Wang,Li-Chao Liu,Ling-Qian Wang,Qing Zhong,Jian-Wei Xie,Jian-Xian Lin,Jun Lu,Long-Long Cao,Mi Lin,Ru-Hong Tu,Chao-Hui Zheng,Ping Li,Chang-Ming Huang
View all publications

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