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AB231067

Anti-FABP4 antibody

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(1 Publication)

Rabbit Polyclonal FABP4 antibody. Suitable for WB and reacts with Rat, Chicken samples. Cited in 1 publication.

View Alternative Names

Adipocyte lipid-binding protein, Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, ALBP, A-FABP, AFABP, Fabp4

4 Images
Western blot - Anti-FABP4 antibody (AB231067)
  • WB

Supplier Data

Western blot - Anti-FABP4 antibody (AB231067)

All lanes:

Western blot - Anti-FABP4 antibody (ab231067) at 2 µg/mL

All lanes:

Rat thymus lysate

Predicted band size: 15 kDa

false

Western blot - Anti-FABP4 antibody (AB231067)
  • WB

Supplier Data

Western blot - Anti-FABP4 antibody (AB231067)

All lanes:

Western blot - Anti-FABP4 antibody (ab231067) at 2 µg/mL

All lanes:

Chicken thymus lysate

Predicted band size: 15 kDa

false

Western blot - Anti-FABP4 antibody (AB231067)
  • WB

Supplier Data

Western blot - Anti-FABP4 antibody (AB231067)

All lanes:

Western blot - Anti-FABP4 antibody (ab231067) at 2 µg/mL

All lanes:

Recombinant chicken FABP4 protein

Predicted band size: 15 kDa

false

Western blot - Anti-FABP4 antibody (AB231067)
  • WB

Supplier Data

Western blot - Anti-FABP4 antibody (AB231067)

All lanes:

Western blot - Anti-FABP4 antibody (ab231067) at 1 µg/mL

All lanes:

Rat heart lysate

Predicted band size: 15 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Chicken

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Chicken": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fatty acid-binding protein 4 (FABP4) also known as aP2 is a member of the fatty acid-binding protein family. It predominantly exists in adipocytes and macrophages serving an important role in lipid metabolism and transport. FABP4 facilitates the binding and transport of long-chain fatty acids and other hydrophobic molecules within cells. The molecular weight of FABP4 is approximately 14-15 kDa. It exhibits high expression levels in adipose tissue and is inducible in macrophages under certain conditions.
Biological function summary

This protein participates in the regulation of lipid homeostasis and energy metabolism. FABP4 is part of the lipid-binding protein family that helps maintain fatty acid equilibrium within cells. By controlling the transport and signaling of lipids FABP4 impacts lipid storage insulin sensitivity and inflammation processes. Its activity is not confined to a specific multimeric complex yet it interacts with other proteins to exert its functions contributing to significant metabolic pathways in the body.

Pathways

FABP4 plays essential roles in the regulation of metabolic and inflammatory signaling pathways. It is intricately involved in the peroxisome proliferator-activated receptor gamma (PPARγ) pathway where it modulates adipose tissue development and glucose metabolism. In addition FABP4 has connections with the c-Jun N-terminal kinase (JNK) signaling pathway influencing stress and inflammatory responses. Interactions with these pathways place FABP4 at a link with proteins like PPARγ and JNK essential for cellular metabolic balance and responses to metabolic stress.

Researchers connect FABP4 to conditions such as obesity and type 2 diabetes. Its expression levels correlate with insulin resistance and metabolic syndrome making it a target of interest in these metabolic disorders. FABP4 interacts with other proteins like adiponectin which is important in modulating glucose levels and fatty acid breakdown. Understanding FABP4's role in these pathways can facilitate the development of therapeutic strategies aimed at targeting metabolic dysfunctions associated with obesity and diabetes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
See full target information Fabp4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Osteoarthritis and cartilage open 5:100359 PubMed37180812

2023

Mild treadmill exercise inhibits cartilage degeneration via macrophages in an osteoarthritis mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Yuichiro Oka,Kenji Murata,Kaichi Ozone,Yuki Minegishi,Takuma Kano,Naoki Shimada,Naohiko Kanemura
View all publications
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Product promise

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