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AB23693

Anti-FABP4 antibody

5

(2 Reviews)

|

(6 Publications)

Rabbit Polyclonal FABP4 antibody. Suitable for WB and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human FABP4 aa 100 to C-terminus.

View Alternative Names

Adipocyte lipid-binding protein, Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, ALBP, A-FABP, AFABP, FABP4

1 Images
Western blot - Anti-FABP4 antibody (AB23693)
  • WB

Unknown

Western blot - Anti-FABP4 antibody (AB23693)

All lanes:

Western blot - Anti-FABP4 antibody (ab23693) at 2 µg/mL

Lane 1:

His-tagged recombinant rat ALBP lysate (1ug)

Lane 2:

rat brown fat (30ug)

Predicted band size: 15 kDa

Observed band size: 15 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FABP4 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P15090

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "<p></p>" }, "Hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 50% Glycerol (glycerin, glycerine), 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fatty acid-binding protein 4 (FABP4) also known as aP2 is a member of the fatty acid-binding protein family. It predominantly exists in adipocytes and macrophages serving an important role in lipid metabolism and transport. FABP4 facilitates the binding and transport of long-chain fatty acids and other hydrophobic molecules within cells. The molecular weight of FABP4 is approximately 14-15 kDa. It exhibits high expression levels in adipose tissue and is inducible in macrophages under certain conditions.
Biological function summary

This protein participates in the regulation of lipid homeostasis and energy metabolism. FABP4 is part of the lipid-binding protein family that helps maintain fatty acid equilibrium within cells. By controlling the transport and signaling of lipids FABP4 impacts lipid storage insulin sensitivity and inflammation processes. Its activity is not confined to a specific multimeric complex yet it interacts with other proteins to exert its functions contributing to significant metabolic pathways in the body.

Pathways

FABP4 plays essential roles in the regulation of metabolic and inflammatory signaling pathways. It is intricately involved in the peroxisome proliferator-activated receptor gamma (PPARγ) pathway where it modulates adipose tissue development and glucose metabolism. In addition FABP4 has connections with the c-Jun N-terminal kinase (JNK) signaling pathway influencing stress and inflammatory responses. Interactions with these pathways place FABP4 at a link with proteins like PPARγ and JNK essential for cellular metabolic balance and responses to metabolic stress.

Researchers connect FABP4 to conditions such as obesity and type 2 diabetes. Its expression levels correlate with insulin resistance and metabolic syndrome making it a target of interest in these metabolic disorders. FABP4 interacts with other proteins like adiponectin which is important in modulating glucose levels and fatty acid breakdown. Understanding FABP4's role in these pathways can facilitate the development of therapeutic strategies aimed at targeting metabolic dysfunctions associated with obesity and diabetes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
See full target information FABP4
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Adipocyte 10:264-274 PubMed33938394

2021

MicroRNA-29b/29c targeting CTRP6 influences porcine adipogenesis via the AKT/PKA/MAPK Signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjing Wu,Ke Xu,Meng Li,Jin Zhang,Yizhen Wang

Aging 12:18942-18956 PubMed33040052

2020

Activation of LKB1 rescues 3T3-L1 adipocytes from senescence induced by Sirt1 knock-down: a pivotal role of LKB1 in cellular aging.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Lan,Yan Lin,Zhenfeng Gao,Jose M Cacicedo,Karen Weikel,Yasuo Ido

Biomolecules 10: PubMed32354097

2020

Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold.

Applications

Unspecified application

Species

Unspecified reactive species

Nausika Betriu,Claire Jarrosson-Moral,Carlos E Semino

Schizophrenia research 177:88-97 PubMed27236410

2016

Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia.

Applications

Unspecified application

Species

Unspecified reactive species

Raquel Pinacho,Núria Villalmanzo,J Javier Meana,Isidre Ferrer,Adriana Berengueras,Josep M Haro,Judit Villén,Belén Ramos

Journal of cellular physiology 230:1033-41 PubMed25251157

2014

Lkb1 deletion promotes ectopic lipid accumulation in muscle progenitor cells and mature muscles.

Applications

Unspecified application

Species

Unspecified reactive species

Tizhong Shan,Pengpeng Zhang,Pengpeng Bi,Shihuan Kuang

The Journal of biological chemistry 288:34394-402 PubMed24133204

2013

MicroRNA-27 (miR-27) targets prohibitin and impairs adipocyte differentiation and mitochondrial function in human adipose-derived stem cells.

Applications

WB

Species

Human

Ting Kang,Wan Lu,Wei Xu,Leonard Anderson,Methode Bacanamwo,Winston Thompson,Y Eugene Chen,Dong Liu
View all publications
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