JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB96122

Anti-FABP6 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal FABP6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FABP6 aa 1 to C-terminus.

View Alternative Names

ILBP, ILLBP, FABP6, Gastrotropin, GT, Fatty acid-binding protein 6, Ileal lipid-binding protein, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-15P, I-BABP

1 Images
Western blot - Anti-FABP6 antibody (AB96122)
  • WB

Unknown

Western blot - Anti-FABP6 antibody (AB96122)

12% SDS-PAGE

All lanes:

Western blot - Anti-FABP6 antibody (ab96122) at 1/1000 dilution

Lane 1:

HeLa S3 whole cell lysate at 30 µg

Lane 2:

HepG2 whole cell lysate at 30 µg

Predicted band size: 14 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human FABP6 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P51161

style
left-column

Complementary Products

Assay Kits

AB313598

Human FABP6 ELISA Kit

Sandwich ELISA - Human FABP6 ELISA Kit (AB313598)

  • 0
  • 0
Primary Antibodies

AB203205

Anti-SLC10A2/ASBT antibody

Western blot - Anti-SLC10A2/ASBT antibody (AB203205)

  • 0
  • 0
Primary Antibodies

AB235094

Anti-Bile Acid Receptor NR1H4 antibody

Western blot - Anti-Bile Acid Receptor NR1H4 antibody (AB235094)

  • 0
  • 0
Primary Antibodies

AB129089

Anti-FXR1 antibody [EPR7932]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-FXR1 antibody [EPR7932] (AB129089)

  • 5
  • 1
Primary Antibodies

AB4794

Anti-FAK (phospho S910) antibody

Western blot - Anti-FAK (phospho S910) antibody (AB4794)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fatty acid-binding protein 6 (FABP6) also known as ileal bile acid binding protein (IBABP) plays a significant role in binding bile acids. This protein weighs approximately 14 kDa and is prominently expressed in the ileum of the small intestine. It functions primarily within the cytoplasm ensuring the transportation of bile acids to specific locations within cells. By doing this FABP6 facilitates the proper metabolism and absorption of these acids which are critical components for the digestion and absorption of dietary fats.
Biological function summary

The protein plays a critical role in the enterohepatic circulation of bile acids which it binds with high affinity. FABP6 operates within a network of ligands and ions aiding in the homeostasis of bile acids. While it does not directly associate with larger complexes its action contributes to maintaining a balance of cholesterol and fats in the body. It also integrates with other fatty acid-binding proteins like FABP1 and FABP3 which engage in similar transport functions in different tissues.

Pathways

FABP6 functions prominently within the bile acid signaling and lipid metabolism pathways. It interacts closely with proteins such as FXR (Farnesoid X receptor) that senses bile acid concentrations and regulates their synthesis and transport. Additionally FABP6 has relationship with the bile acid-CoA:amino acid N-acyltransferase (BAAT) which is involved in bile acid conjugation. These connections underpin its key role in lipid digestion and cholesterol homeostasis.

FABP6 has associations with cholestasis and Crohn’s disease. In cholestasis impaired bile flow can arise from the dysfunction of bile acid transport to which FABP6 is linked. Furthermore alterations in the protein’s expression or function contribute to Crohn’s disease particularly in the ileal region where it heavily expresses. Mutations and malfunction of related proteins such as FXR and BAAT can complement or exacerbate these issues solidifying the importance of FABP6 in maintaining gut and liver health.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order : deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).. Isoform 2. Essential for the survival of colon cancer cells to bile acid-induced apoptosis.
See full target information FABP6
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Mitochondrion 34:115-126 PubMed28288917

2017

Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice.

Applications

Unspecified application

Species

Unspecified reactive species

Viktoria Vereczki,Josef Mansour,Issa Pour-Ghaz,Ibolya Bodnar,Otto Pinter,Dora Zelena,Erzsebet Oszwald,Vera Adam-Vizi,Christos Chinopoulos
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com