Mouse Monoclonal Factor D/CFD antibody. Suitable for WB, sELISA and reacts with Human samples. Immunogen corresponding to Full Length Protein corresponding to Human CFD.
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 97% Phosphate Buffer, 2.9% Sodium chloride
| WB | sELISA | |
|---|---|---|
| Human | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes as capture antibody. The dilution guideline for ELISA is based on sandwich ELISA in combination with a polyclonal antibody against the antigen. |
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Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
DF, PFD, CFD, Complement factor D, Adipsin, C3 convertase activator, Properdin factor D
Mouse Monoclonal Factor D/CFD antibody. Suitable for WB, sELISA and reacts with Human samples. Immunogen corresponding to Full Length Protein corresponding to Human CFD.
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 97% Phosphate Buffer, 2.9% Sodium chloride
ab121054 is specific for complement Factor D/CFD in Human serum and plasma.
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Factor D also known as complement factor D or CFD protein is a serine protease involved in the alternative pathway of the complement system. It plays a mechanical role by cleaving factor B when it is bound to C3b forming the active C3 convertase C3bBb. This enzyme is relatively small with a mass of approximately 28.5 kDa. It is mainly expressed in adipose tissue but it can also be found in the blood plasma.
Factor D aids the immune system's ability to destroy pathogens. As part of the alternative complement pathway it acts independently and does not associate with larger protein complexes. Its activation of the alternative pathway leads to direct lysis of pathogens therefore contributing to innate immunity.
Factor D participates specifically in the complement activation pathway particularly in the innate immune response. It works closely with other proteins in the complement system such as factor B and C3. This pathway enhances the opsonization and removal of microbes and damaged cells acting in parallel with the classical pathway of the complement system.
Abnormal function or regulation of factor D can relate to chronic inflammation and age-related macular degeneration. Disorders involving factor D may involve excess complement activation leading to tissue damage. The role of factor D in these diseases often connects it to other key complement components such as C3 and factor B which can also become problematic when dysregulated.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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