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AB81460

Anti-Factor Va antibody

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(1 Publication)

Sheep Polyclonal Factor V antibody. Suitable for ELISA, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human F5.

View Alternative Names

Coagulation factor V, Activated protein C cofactor, F5

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ELISA

applications

Immunogen

Native Full Length Protein corresponding to Human F5.

P12259

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Reactivity data

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Product details

Concentration 5-10mg/ml (lot specific).
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Properties and storage information

Form
Liquid
Purification technique
Ion exchange chromatography
Purification notes
Salt fractionation followed by ion exchange chromatography on DEAE sepharose.
Storage buffer
Constituents: 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Factor Va also known as activated factor V plays a central role in blood coagulation. It forms a part of the prothrombinase complex which accelerates the conversion of prothrombin to thrombin an important step in the clotting process. Factor Va is a cofactor protein with a molecular mass of approximately 330 kDa. It is expressed primarily in platelets and plasma and its availability is increased during coagulation through activation by thrombin.
Biological function summary

Factor Va acts as an important component of the blood coagulation cascade. It forms a complex with factor Xa on phospholipid surfaces creating the tenase complex which is essential for the efficient conversion of prothrombin to thrombin. This complexation greatly increases the enzymatic efficiency of thrombin generation which is important for clot formation and stabilization. Factor Va's activity is regulated by activated protein C which inactivates factor Va to prevent excessive clotting.

Pathways

Factor Va significantly impacts the intrinsic and extrinsic pathways of blood coagulation. It directly interacts with factor Xa in the prothrombinase complex driving thrombin production. Thrombin in turn activates fibrinogen to fibrin promoting clot stabilization. The intrinsic and extrinsic pathways converge on factor Xa making its interaction with factor Va a shared critical point. This relationship emphasizes how factor Va integrates into broader coagulation processes.

Factor Va's role in the coagulation pathway makes it pivotal for conditions like thrombophilia and factor V Leiden. Anomalies in factor Va can lead to inappropriate clot formation contributing to thrombophilic disorders. The factor V Leiden mutation results from a change in the factor V gene rendering factor Va resistant to inactivation by activated protein C therefore increasing thrombotic risk. Understanding these interactions provides insights into pathologies involving coagulopathy.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
See full target information F5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Lung cellular and 309:L942-58 PubMed26320158

2015

Characterization of the platelet-derived growth factor receptor-α-positive cell lineage during murine late lung development.

Applications

Unspecified application

Species

Unspecified reactive species

Aglaia Ntokou,Friederike Klein,Daria Dontireddy,Sven Becker,Saverio Bellusci,William D Richardson,Marten Szibor,Thomas Braun,Rory E Morty,Werner Seeger,Robert Voswinckel,Katrin Ahlbrecht
View all publications
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